QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Desroches, S. Articles by Lamarche, B. Search for Related Content PubMed PubMed Citation Articles by Desroches, S. Articles by Lamarche, B.

---

Human Nutrition and Metabolism

Soy Protein Favorably Affects LDL Size Independently of Isoflavones in Hypercholesterolemic Men and Women¹

Institute on Nutraceuticals and Functional Foods, Laval University, Ste-Foy, Québec, Canada, G1K 7P4 and ^* Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111

²To whom correspondence should be addressed. E-mail: benoit.lamarche{at}inaf.ulaval.ca.

We assessed the independent effect of soy protein relative to animal protein and of isoflavones on various electrophoretic characteristics of LDL particles. LDL particles were characterized by polyacrylamide gradient gel electrophoresis in 36 moderately hypercholesterolemic men and women (LDL cholesterol > 3.36 mmol/L). All subjects consumed in random order each of the four diets (soy protein depleted of isoflavones, soy protein enriched in isoflavones, animal protein with no added isoflavones, and animal protein with added isoflavones) for 6 wk. Consumption of soy protein was associated with a larger LDL peak particle size relative to animal protein (P < 0.01). Soy protein also decreased the cholesterol levels in LDL < 25.5 nm by 12.3% (P < 0.001) and increased cholesterol levels in LDL > 26.0 nm by 14.3% (P < 0.05) relative to animal protein. Isoflavones did not affect these LDL particle characteristics. Soy protein shifted LDL particle distribution to a less atherogenic pattern and this effect is independent of soy’s isoflavone component.

KEY WORDS: • soy protein • isoflavones • lipoproteins • lipids • LDL size

This article has been cited by other articles:

				C. D. Gardner, M. Messina, A. Kiazand, J. L. Morris, and A. A. Franke Effect of Two Types of Soy Milk and Dairy Milk on Plasma Lipids in Hypercholesterolemic Adults: A Randomized Trial J. Am. Coll. Nutr., December 1, 2007; 26(6): 669 - 677. [Abstract] [Full Text] [PDF]

				S. Shrestha, H. C. Freake, M. M. McGrane, J. S. Volek, and M. L. Fernandez A Combination of Psyllium and Plant Sterols Alters Lipoprotein Metabolism in Hypercholesterolemic Subjects by Modifying the Intravascular Processing of Lipoproteins and Increasing LDL Uptake J. Nutr., May 1, 2007; 137(5): 1165 - 1170. [Abstract] [Full Text] [PDF]

				K. Taku, K. Umegaki, Y. Sato, Y. Taki, K. Endoh, and S. Watanabe Soy isoflavones lower serum total and LDL cholesterol in humans: a meta-analysis of 11 randomized controlled trials Am. J. Clinical Nutrition, April 1, 2007; 85(4): 1148 - 1156. [Abstract] [Full Text] [PDF]

				S. Shrestha, J. S. Volek, J. Udani, R. J.Wood, C. M. Greene, D. Aggarwal, J. H. Contois, B. Kavoussi, and M. L. Fernandez A Combination Therapy Including Psyllium and Plant Sterols Lowers LDL Cholesterol by Modifying Lipoprotein Metabolism in Hypercholesterolemic Individuals J. Nutr., October 1, 2006; 136(10): 2492 - 2497. [Abstract] [Full Text] [PDF]

				M. Takahashi, T. Sekine, N. Kuba, S. Nakamori, M. Yasuda, and H. Takagi The Production of Recombinant APRP, an Alkaline Protease Derived from Bacillus pumilus TYO-67, by In Vitro Refolding of Pro-enzyme Fixed on a Solid Surface J. Biochem., October 1, 2004; 136(4): 549 - 556. [Abstract] [Full Text] [PDF]