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Diagnostic Systems Laboratories, Incorporated, Webster, TX 77598 and * Beth Israel Deaconess Medical Center, Department of Endocrinology Diabetes and Metabolism, RN 325, Boston, MA 02215
2To whom correspondence should be addressed. E-mail: cmantzor{at}bidmc.harvard.edu.
Health problems resulting from obesity could offset many of the recent health gains achieved by modern medicine, and obesity may replace tobacco as the number one health risk for developed societies. An estimated 300,000 deaths per year and significant morbidity are directly attributable to obesity, mainly due to heart disease, diabetes, cancer, asthma, sleep apnea, arthritis, reproductive complications and psychological disturbances. In parallel with the increasing prevalence of obesity, there has been a dramatic increase in the number of scientific and clinical studies on the control of energy homeostasis and the pathogenesis of obesity to further our understanding of energy balance. It is now recognized that there are many central and peripheral factors involved in energy homeostasis, and it is expected that the understanding of these mechanisms should lead to effective treatments for the control of obesity. This brief review discusses the potential role of several recently discovered molecular pathways involved in the control of energy homeostasis, obesity and eating disorders.
KEY WORDS: • obesity • energy homeostasis • leptin • ghrelin • insulin • adiponectin • resistin • peptide YY3-36
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