QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Perona, J. S. Articles by Ruiz-Gutierrez, V. Search for Related Content PubMed PubMed Citation Articles by Perona, J. S. Articles by Ruiz-Gutierrez, V.

---

Human Nutrition and Metabolism

The Unsaponifiable Fraction of Virgin Olive Oil in Chylomicrons from Men Improves the Balance between Vasoprotective and Prothrombotic Factors Released by Endothelial Cells¹

Instituto de la Grasa (CSIC), 41012 Sevilla, Spain and ^* Centro de Investigación Cardiovascular, CSIC-ICCC, Hospital de la Santa Creu i Sant Pau, 08025 Barcelona, Spain

²To whom correspondence should be addressed. E-mail: valruiz{at}ig.csic.es.

Minor components of virgin olive oil (VOO) may play a key role in the beneficial effects of VOO on atherosclerosis. In the present study we evaluated the influence of the unsaponifiable fraction of VOO on the production of eicosanoids and nitric oxide (NO) by endothelial cells (HUVECs). Triglyceride-rich lipoprotein (TRLs) were isolated from human serum after the intake of meals enriched in 3 high-oleic acid oils, i.e., high-oleic sunflower (HOSO), VOO, or enriched-virgin olive (EVO) oils, the last-mentioned containing 2.4% of unsaponifiable matter. HOSO induced a greater accumulation of triglycerides (TGs) in the postprandial serum than VOO or EVO, as measured by calculating the area under the curve. The incubation with TRLs increased NO release by endothelial cells compared with untreated control cells, but the effects of the various TRLs did not differ. EVO-derived TRLs reduced the production of prostaglandin E₂ (PGE₂) and thromboxane B₂ (TxB₂) (the stable metabolite of TxA₂) compared with VOO- or HOSO-derived TRLs. The release of PGI₂ (as 6-keto PGF₁) was similarly diminished by all TRLs compared with the control. In conclusion, the unsaponifiable fraction of VOO does not affect postprandial triglyceridemia, but it has favorable effects on endothelial function, mainly by reducing proinflammatory and vasoconstrictor eicosanoid synthesis (PGE₂ and TxB₂).

KEY WORDS: • unsaponifiable matter • virgin olive oil • triglyceride-rich lipoprotein • endothelial • eicosanoids

This article has been cited by other articles:

				J. Martinez-Gonzalez, R. Rodriguez-Rodriguez, M. Gonzalez-Diez, C. Rodriguez, M. D. Herrera, V. Ruiz-Gutierrez, and L. Badimon Oleanolic Acid Induces Prostacyclin Release in Human Vascular Smooth Muscle Cells through a Cyclooxygenase-2-Dependent Mechanism J. Nutr., March 1, 2008; 138(3): 443 - 448. [Abstract] [Full Text] [PDF]

				R. Cabello-Moruno, J. S. Perona, J. Osada, M. Garcia, and V. Ruiz-Gutierrez Modifications in Postprandial Triglyceride-Rich Lipoprotein Composition and Size after the Intake of Pomace Olive Oil J. Am. Coll. Nutr., February 1, 2007; 26(1): 24 - 31. [Abstract] [Full Text] [PDF]