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© 2004 The American Society for Nutritional Sciences J. Nutr. 134:5-10, January 2004

Biochemical and Molecular Actions of Nutrients

Dietary Resveratrol Does Not Affect Intestinal Tumorigenesis in ApcMin/+ Mice1

Carol C. Ziegler, Leah Rainwater*, Jay Whelan and Michael F. McEntee*,2

Department of Nutrition and * Department of Pathology, University of Tennessee, Knoxville, TN

2To whom correspondence should be addressed. E-mail: mmcentee{at}utk.edu.

To determine its effect on intestinal tumorigenesis and the protumorigenic COX pathway in ApcMin/+ mice, resveratrol was administered as a powdered admixture in the diet at 0, 4, 20, or 90 mg/kg body weight for 7 wk. In two separate experiments, resveratrol did not affect intestinal tumor load. It was stable in the diet under experimental conditions, circulated in the plasma as the glucuronide-conjugated form and reached the tumors as evidenced by significant decreases in PGE2 levels. However, immunohistochemical staining of intestinal tumors revealed no changes in COX-2 expression. This study demonstrates that resveratrol consumed ad libitum in the diet, does not modify tumorigenesis in ApcMin/+ mice.

KEY WORDS: • cancer • resveratrol • Apc • phytochemical • COX-2




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