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Supplement: Proceedings of Symposium to Honor the Memory of James Allen Olson

From 1989 to 2001: What Have We Learned About the "Biological Actions of Beta-Carotene"?¹

Clinical Director, Medical Affairs, GlaxoSmithKline, 1500 Littleton Rd., Parsippany, NJ 07054

²To whom correspondence should be addressed. E-mail: Adrianne.4.Bendich{at}gsk.com.

Dr. James Allen Olson helped us to define the role of beta-carotene in human health by categorizing these as "functions, actions and associations." In the last decade, significant research has shown that beta-carotene acts as an antioxidant in biologically relevant systems, affects several aspects of human immune function and higher intake/serum levels are associated with improvements in certain physiological functions such as lung function. The unexpected findings of increased lung cancer in beta-carotene supplemented smokers in the ATBC and CARET intervention studies have resulted in the need for expanded research efforts to define the mechanism(s) of action of beta-carotene. Recent survey data as well as laboratory animal studies continue to find an inverse association between beta-carotene and cancer risk. Because beta-carotene is the major source of vitamin A for the majority of the world’s population, it is critical to define the safe levels of intake from foods and supplements.

KEY WORDS: • immune function • lung function • antioxidant • cancer • lipids

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