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© 2003 The American Society for Nutritional Sciences J. Nutr. 133:2494S-2496S, July 2003

Supplement: Nutritional Genomics and Proteomics in Cancer Prevention

Models for Assessing the Role of Selenoproteins in Health1

Mohamed E. Moustafa, Easwari Kumaraswamy, Nianxin Zhong, Mahadev Rao, Bradley A. Carlson and Dolph L. Hatfield2

Section on the Molecular Biology of Selenium, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892

2 To whom correspondence should be addressed. E-mail: hatfield{at}dc37a.nci.nih.gov.

Two model systems for examining the role of selenoproteins in health are discussed. One utilizes transgenic mice that carry mutant selenocysteine (Sec) tRNA transgenes that result in the reduction of selenoprotein expression in a protein- and tissue-specific manner. The other utilizes loxP-Cre technology to selectively remove the Sec tRNA gene in mammary epithelium that results in the reduction of only certain selenoproteins in this tissue. Both approaches provide important tools for examining the role of selenoproteins in health.

KEY WORDS: • conditional knockout mice • selenium • selenocysteine • selenocysteine tRNA • transgenic mice




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