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Nutrient Metabolism
Research Communication

Feeding Minipigs Fish Oil for Four Weeks Lowers Postprandial Triacylglycerolemia

Lone Frost Larsen^*,2, Aage Kristian Olsen^*,,**, Axel Kornerup Hansen, Klaus Bukhave^* and Peter Marckmann^*

^* Department of Human Nutrition and Centre for Advanced Food Studies and Division of Laboratory Animal Science and Welfare, Department of Pharmacology and Pathobiology, Royal Veterinary and Agricultural University, Frederiksberg, Denmark; and ^** Department of Thrombosis Research, The University of Southern Denmark, and Department of Clinical Biochemistry, Ribe County Hospital, Esbjerg, Denmark

²To whom correspondence should be addressed. E-mail: lfla{at}novonordisk.com.

We wanted to establish a minipig model for the study of postprandial lipemia and plasma lipid clearance after fish oil consumption. Seven minipigs were fed a fish oil–enriched nonpurified diet and a control diet for 4 wk in a randomized cross-over study. After each intervention period, each pig was challenged with a gastric fat load (2 g fat/kg body) and an intravenous fat bolus (0.1 g/kg body) on separate days. Frequent blood samples were collected for 6 h after the gastric fat load and for 40 min after the intravenous bolus. The fish oil–enriched diet was associated with lower triacylglycerol, glycerol and nonesterified fatty acid concentrations in the hours after the gastric fat load than the control diet (P < 0.05). In contrast, the triacylglycerol disappearance rate after the intravenous fat bolus was not affected by fish oil (P = 0.19). In conclusion, dietary fish oil supplementation attenuates postprandial lipemia in minipigs similarly to what occurs in humans. Minipigs could serve as a useful model for future studies of this phenomenon. We observed no significant effect of fish oil supplementation on plasma triacylglycerol clearance and thus were unable to identify the mechanism explaining the attenuated lipemia in minipigs.

KEY WORDS: • lipid clearance • pigs • triacylglycerol