Journal of Nutrition OpenSOurce Diets- www.ResearchDiets.com

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Folmer, V.
Right arrow Articles by Rocha, J. B. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Folmer, V.
Right arrow Articles by Rocha, J. B. T.

© 2003 The American Society for Nutritional Sciences J. Nutr. 133:2165-2170, July 2003

Biochemical and Molecular Actions of Nutrients

A High Fat Diet Inhibits {delta}-Aminolevulinate Dehydratase and Increases Lipid Peroxidation in Mice (Mus musculus)

Vanderlei Folmer, Júlio C. M. Soares, Diogo Gabriel and João B. T. Rocha2

Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, 97105–900, Santa Maria, RS, Brasil

2To whom correspondence should be addressed. E-mail: jbtrocha{at}yahoo.com.br.

The aim of this study was examine the effects of high starch (HS) vs. high fat (HF) feeding on blood glycated hemoglobin (GHbA1c) level, thiobarbituric acid-reactive species (TBA-RS) concentration and {delta}-aminolevulinate dehydratase ({delta}-ALA-D) activity in mice. The GHbA1c level was significantly higher in mice fed the HF diet compared with those fed the HS diet. Hepatic, renal, and cerebral TBA-RS concentrations in mice fed the HF diet were significantly greater than in mice fed the HS diet. In addition, positive correlations were found between the GHbA1c and TBA-RS levels for hepatic (P < 0.05; r = 0.46), renal (P < 0.003; r = 0.65), and cerebral (P < 0.001; r = 0.69) tissues. The {delta}-ALA-D hepatic, renal and cerebral activities of mice fed the HF diet were significantly lower than those of mice fed the HS diet. Furthermore, a negative correlation was found between the GHbA1c level and {delta}-ALA-D activity in hepatic (P < 0.001; r = -0.77), renal (P < 0.007; r = -0.60), and cerebral (P < 0.007; r = -0.60) tissues. The results of this study indicate that consumption of a high fat diet promotes oxidative stress related to hyperglycemia, which in turn can stimulate glycation of proteins leading to {delta}-ALA-D inhibition in mice.

KEY WORDS: • high fat diet • hyperglycemia • oxidative stress • {delta}-aminolevulinate dehydratase • mice




This article has been cited by other articles:


Home page
 J. Nutr.Home page
F. Kamp and C. M. Donangelo
Supplementing Young Women with Both Zinc and Iron Protects Zinc-Related Antioxidant Indicators Previously Impaired by Iron Supplementation
J. Nutr., November 1, 2008; 138(11): 2186 - 2189.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
P. Bermejo-Alvarez, D. Rizos, D. Rath, P. Lonergan, and A. Gutierrez-Adan
Can Bovine In Vitro-Matured Oocytes Selectively Process X- or Y-Sorted Sperm Differentially?
Biol Reprod, October 1, 2008; 79(4): 594 - 597.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
F. S. Gravina, C. K. B. da Silveira, A. M. de Assis, D. K. Rieger, C. Guerini, A. P. Muller, M. Farina, L. N. Rotta, and M. L. S. Perry
Experimental Hypothyroidism Inhibits {delta}-Aminolevulinate Dehydratase Activity in Neonatal Rat Blood and Liver
Experimental Biology and Medicine, September 1, 2007; 232(8): 1021 - 1026.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Copyright © 2003 by American Society for Nutrition