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Human Nutrition and Metabolism

Dietary Mono- and Polyunsaturated Fatty Acids Similarly Increase Plasma Apolipoprotein A-IV Concentrations in Healthy Men and Women

Mario Kratz², Ursel Wahrburg^*, Arnold von Eckardstein, Benjie Ezeh^**, Gerd Assmann and Florian Kronenberg^**,

Institute of Arteriosclerosis Research at the University of Münster, 48149 Münster, Germany; ^* University of Applied Sciences, 48151 Münster, Germany; Institute of Clinical Chemistry and Laboratory Medicine, University of Zürich, 8091 Zürich, Switzerland; ^** Institute of Medical Biology and Human Genetics, University of Innsbruck, 6020 Innsbruck, Austria; GSF-National Research Center for Environment and Health, Institute of Epidemiology, 85764 Neuherberg, Germany

²To whom correspondence and reprint requests should be addressed. E-mail: mkratz{at}uni-muenster.de.

We investigated the effect of dietary fatty acid composition on plasma apolipoprotein (apo) A-IV concentrations. Plasma apo A-IV concentrations were measured by ELISA in plasma of 48 healthy men and women in a controlled dietary study. First, all participants consumed a 2-wk baseline diet rich in saturated fatty acids (SFA). Then, they were randomly assigned to one of three dietary treatments, which contained refined olive oil [rich in monounsaturated fatty acids (MUFA), n = 17], rapeseed oil {rich in MUFA and -linolenic acid [18:3(n-3)], n = 13}, or sunflower oil [rich in (n-6) PUFA, n = 18] as the principal source of fat for 4 wk. The plasma concentrations of apo A-IV increased when subjects consumed the diets rich in unsaturated fatty acids, by 16% or 13.0 mg/L [F_(2,76) = 12.874, P < 0.001 by repeated-measures ANOVA]. The increase was not affected by diet group affiliation, gender or apo A-IV genotype. In conclusion, diets rich in unsaturated fatty acids, independent of the degree of unsaturation, gender and apo A-IV genotype, increase plasma apo A-IV concentrations compared with a baseline diet rich in SFA in healthy men and women.

KEY WORDS: • monounsaturated fatty acids • polyunsaturated fatty acids • chylomicrons • absorption • humans

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