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Supplement: 11th International Symposium on Trace Elements in Man and Animals

Analytical Methods: Improvements, Advancements and New Horizons ¹

Carl L. Keen^*, Thomas Jue, Cuong D. Tran^**, John Vogel^*,, R. Gregory Downing, Venkatesh Iyengar and Robert B. Rucker^*,2

^* Department of Nutrition, University of California, Davis, Davis, CA, Biological Chemistry, School of Medicine, University of California, Davis, Davis, CA, ^** Gastroenterology Unit, Women's and Children's Hospital, North Adelaide, SA, Australia, Center for Accelerator Mass Spectrometry, Lawrence Livermore National Laboratory, Livermore, CA, R. G. D. Research, Inc., Niskayuna, New York and Nutritional & Health-Related Environmental Studies Section International Atomic Energy Agency, Vienna, Austria

² To whom correspondence should be addressed. Email: rbrucker{at}ucdavis.edu.

The workshop and exhibits dealing with analytical methods were selected to highlight the current state of the art in elemental analysis. The presentations in the first part of the workshop described approaches and advances important to the analysis of trace minerals. These presentations included: 1) two approaches to mass spectrometry, inductively coupled plasma and accelerator mass spectrometry; 2) use of nuclear magnetic resonance in studies of mineral function; and 3) the use and limitations of fluorescent probes in studies of metal uptake and regulation. In the second part of the workshop, the International Atomic Energy's contributions to nutritional "metrology" were described. Advances in instrumentation over the past decade have led to extraordinary improvements in the precision and sensitivity of mineral analyses. The ability to address isotopic speciation at such low levels sets the stage for numerous novel approaches in the assessment of trace mineral function.

KEY WORDS: • fluorescent probes • nuclear magnetic resonance • inductively coupled plasma-mass spectrometry • accelerator mass spectrometry • metrology