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Supplement: 11th International Symposium on Trace Elements in Man and Animals

Marginal Dietary Selenium Intakes in the UK: Are There Functional Consequences? ¹

Department of Medicine, University of Liverpool, Liverpool, L69 3GA, UK

² To whom correspondence should be addressed. E-mail: mjj{at}liv.ac.uk.

Much data indicate that overt selenium deficiency induces a number of pathologies in animals and humans. The effects of chronic marginal undernutrition of this element are unclear, although it has been argued that such subjects will be at increased risk of developing various cancers. The dietary intake of selenium in the UK has fallen over the last 25 years, although no functional consequences of this have been recognized. Recent data demonstrate that restoration of selenium intakes in UK subjects induces biochemical effects with increased activity of selenium-dependent enzymes. Whether such biochemical changes are associated with functional changes is currently unclear and the subject of current investigation.

KEY WORDS: • immune function • selenium-dependent enzymes • viral replication