Journal of Nutrition OpenSOurce Diets- www.ResearchDiets.com

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Beard, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Beard, J.

© 2003 The American Society for Nutritional Sciences J. Nutr. 133:1468S-1472S, May 2003

Supplement: 11th International Symposium on Trace Elements in Man and Animals

Iron Deficiency Alters Brain Development and Functioning 1 ,2

John Beard3

Graduate Program in Nutrition, The Pennsylvania State University, University Park, PA 16802

3 To whom correspondence should be addressed. E-mail: its{at}psu.edu.

Iron deficiency anemia in early life is related to altered behavioral and neural development. Studies in human infants suggest that this is an irreversible effect that may be related to changes in chemistry of neurotransmitters, organization and morphology of neuronal networks, and neurobiology of myelination. The acquisition of iron by the brain is an age-related and brain-region-dependent process with tightly controlled rates of movement of iron across the blood-brain barrier. Dopamine receptors and transporters are altered as are behaviors related to this neurotransmitter. The growing body of evidence suggests that brain iron deficiency in early life has multiple consequences in neurochemistry and neurobiology.

KEY WORDS: • iron deficiency • brain development • behavior • rats • humans • neurotransmitters




This article has been cited by other articles:


Home page
 J Pediatr PsycholHome page
F. Corapci, A. Calatroni, N. Kaciroti, E. Jimenez, and B. Lozoff
Longitudinal Evaluation of Externalizing and Internalizing Behavior Problems Following Iron Deficiency in Infancy
J. Pediatr. Psychol., September 7, 2009; (2009) jsp065v1.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
J. R. Connor, X.-S. Wang, R. P. Allen, J. L. Beard, J. A. Wiesinger, B. T. Felt, and C. J. Earley
Altered dopaminergic profile in the putamen and substantia nigra in restless leg syndrome
Brain, September 1, 2009; 132(9): 2403 - 2412.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
I. Cetin, C. Berti, and S. Calabrese
Role of micronutrients in the periconceptional period
Hum. Reprod. Update, June 30, 2009; (2009) dmp025v1.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
G. Joslyn, G. Brush, M. Robertson, T. L. Smith, J. Kalmijn, M. Schuckit, and R. L. White
Chromosome 15q25.1 genetic markers associated with level of response to alcohol in humans
PNAS, December 23, 2008; 105(51): 20368 - 20373.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
E. L. Unger, J. A. Wiesinger, L. Hao, and J. L. Beard
Dopamine D2 Receptor Expression Is Altered by Changes in Cellular Iron Levels in PC12 Cells and Rat Brain Tissue
J. Nutr., December 1, 2008; 138(12): 2487 - 2494.
[Abstract] [Full Text] [PDF]

Home page
 Nutr Clin PractHome page
S. F. Clark
Iron Deficiency Anemia
Nutr Clin Pract, April 1, 2008; 23(2): 128 - 141.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
J. L. Beard, E. L. Unger, L. E. Bianco, T. Paul, S. E. Rundle, and B. C. Jones
Early Postnatal Iron Repletion Overcomes Lasting Effects of Gestational Iron Deficiency in Rats
J. Nutr., May 1, 2007; 137(5): 1176 - 1182.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
J. C McCann and B. N Ames
An overview of evidence for a causal relation between iron deficiency during development and deficits in cognitive or behavioral function
Am. J. Clinical Nutrition, April 1, 2007; 85(4): 931 - 945.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
L. L Iannotti, J. M Tielsch, M. M Black, and R. E Black
Iron supplementation in early childhood: health benefits and risks
Am. J. Clinical Nutrition, December 1, 2006; 84(6): 1261 - 1276.
[Abstract] [Full Text] [PDF]

Home page
 The Journal of School NursingHome page
S. K. Malone
Improving the Quality of Students' Dietary Intake in the School Setting
The Journal of School Nursing, April 1, 2005; 21(2): 70 - 76.
[Abstract] [Full Text] [PDF]

Home page
 Arch Pediatr Adolesc MedHome page
E. Konofal, M. Lecendreux, I. Arnulf, and M.-C. Mouren
Iron Deficiency in Children With Attention-Deficit/Hyperactivity Disorder
Arch Pediatr Adolesc Med, December 1, 2004; 158(12): 1113 - 1115.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
J. G. Penland and J. R. Prohaska
Abnormal Motor Function Persists Following Recovery from Perinatal Copper Deficiency in Rats
J. Nutr., August 1, 2004; 134(8): 1984 - 1988.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
D. Chu, R. D. Bungiro, M. Ibanez, L. M. Harrison, E. Campodonico, B. F. Jones, J. Mieszczanek, P. Kuzmic, and M. Cappello
Molecular Characterization of Ancylostoma ceylanicum Kunitz-Type Serine Protease Inhibitor: Evidence for a Role in Hookworm-Associated Growth Delay
Infect. Immun., April 1, 2004; 72(4): 2214 - 2221.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
M. M. Black
Micronutrient Deficiencies and Cognitive Functioning
J. Nutr., November 1, 2003; 133(11): 3927S - 3931.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Copyright © 2003 by American Society for Nutrition