QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Heaney, R. P. Search for Related Content PubMed PubMed Citation Articles by Heaney, R. P.

---

Nutritional Methodology
Research Communication

Quantifying Human Calcium Absorption Using Pharmacokinetic Methods

Osteoporosis Research Center, Creighton University, Omaha, NE

²To whom correspondence should be addressed. E-mail: rheaney{at}creighton.edu.

Calcium absorption was measured simultaneously by tracer and pharmacokinetic methods in 12 men. The purpose of the study was to calibrate the area under the curve (AUC) for absorptive calcemia to permit comparison or pooling of pharmacokinetic data with tracer-derived estimates. Each subject was studied twice during intake of 500 mg calcium loads (as the carbonate salt), once without excipients, and once with a binder that impeded dissolution of the salt, reducing its absorbability and thereby providing a broad range of absorption values over which to calibrate the method. Various time periods were evaluated, with the best prediction being given by the AUC for the increment in serum calcium calculated over 9 h (AUC₉). For net absorbed calcium (mmol) the relationship was given by 4.358 x AUC₉ ± 0.820. The empirical regression coefficient was significant and the error of the estimate (0.820 mmol) acceptably small.

KEY WORDS: • calcium absorption • calcium absorption measurement • pharmacokinetic methods • area under the curve

This article has been cited by other articles:

				T. B. Drueke and J. Chanard Oral calcium load and fractional intestinal calcium absorption Nephrol. Dial. Transplant., October 1, 2008; 23(10): 3368 - 3369. [Full Text] [PDF]

				M. J. Barger-Lux, K. M. Davies, and R. P. Heaney Calcium Supplementation Does Not Augment Bone Gain in Young Women Consuming Diets Moderately Low in Calcium J. Nutr., October 1, 2005; 135(10): 2362 - 2366. [Abstract] [Full Text] [PDF]

				R. P. Hanzlik, S. C. Fowler, and D. H. Fisher Relative Bioavailability of Calcium from Calcium Formate, Calcium Citrate, and Calcium Carbonate J. Pharmacol. Exp. Ther., June 1, 2005; 313(3): 1217 - 1222. [Abstract] [Full Text] [PDF]