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© 2003 The American Society for Nutritional Sciences J. Nutr. 133:808-813, March 2003

Food Products Containing Free Tall Oil-Based Phytosterols and Oat ß-Glucan Lower Serum Total and LDL Cholesterol in Hypercholesterolemic Adults1

Kevin C. Maki2, Fred Shinnick*, Marlyn A. Seeley, Patricia E. Veith, Laura C. Quinn, Pamela J. Hallissey, Arlene Temer and Michael H. Davidson

Chicago Center for Clinical Research, Chicago, IL and * Altus Food Company, Chicago, IL

2To whom correspondence should be addressed. E-mail: kmaki{at}protocare.com

This randomized, double-blind, controlled trial evaluated the influence of low fat, low saturated fat food products that contained free tall oil–based phytosterols (TOP) and oat ß-glucan (from whole oats and bran concentrate) on serum lipid concentrations in adults with mild-to-moderate hypercholesterolemia. After a 5-wk National Cholesterol Education Program Step I diet lead-in period, 112 subjects incorporated one of two treatments into their diets for 6 wk: food products (cereal, snack bar and beverage) that provided 1.8 g TOP and 2.8 g ß-glucan/d and contained <=3.0 g total fat and <=1.0 g saturated fat (TOP/ß-glucan treatment) or similar control foods. The serum LDL cholesterol response from baseline to the end of study was significantly larger in the TOP/ß-glucan treated group than in the control group, in which there was no change (-3.7 vs. 0.4%; P = 0.013). Likewise, total cholesterol decreased in the TOP/ß-glucan treatment group and did not change significantly in the controls (-2.3 vs. 0.8%; P = 0.043). Serum HDL cholesterol and triglyceride responses did not differ between the groups. The results of this trial suggest that consumption of a group of low fat, TOP and ß-glucan– containing foods is a useful adjunct in the dietary management of hypercholesterolemia.

KEY WORDS: • hypercholesterolemia • lipids • tall oil • phytosterols • ß-glucan






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