![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Nutrition/Metabolism Laboratory, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
2To whom correspondence should be addressed. E-mail: jrzhou{at}caregroup.harvard.edu
Although high doses of single bioactive agents may have potent anticancer effects, the chemopreventive properties of the Asian diet may result from interactions among several components that potentiate the activities of any single constituent. In Asia, where intake of soy products and tea consumption are very high, aggressive prostate cancer is significantly less prevalent in Asian men. The objective of the present study was to identify possible synergistic effects between soy and tea components on prostate tumor progression in a mouse model of orthotopic androgen-sensitive human prostate cancer. Soy phytochemical concentrate (SPC), black tea and green tea were compared with respect to tumorigenicity rate, primary tumor growth, tumor proliferation index and microvessel density, serum androgen level and metastases to lymph nodes. SPC, black tea and green tea significantly reduced tumorigenicity. SPC and black tea also significantly reduced final tumor weights. Green tea did not reduce final tumor weight, although it tended to elevate (P = 0.14) the serum dihydrotestosterone (DHT) concentration. The combination of SPC and black tea synergistically inhibited prostate tumorigenicity, final tumor weight and metastases to lymph nodes in vivo. The combination of SPC and green tea synergistically inhibited final tumor weight and metastasis and significantly reduced serum concentrations of both testosterone and DHT in vivo. Inhibition of tumor progression was associated with reduced tumor cell proliferation and tumor angiogenesis. This study suggests that further research is warranted to study the role of soy and tea combination as effective nutritional regimens in prostate cancer prevention.
KEY WORDS: • prostate cancer • soy phytochemicals • tea • synergy
This article has been cited by other articles:
|
|
 |
|
  L. Yan and E. L Spitznagel Soy consumption and prostate cancer risk in men: a revisit of a meta-analysis Am. J. Clinical Nutrition, April 1, 2009; 89(4): 1155 - 1163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-R. Zhou, G. L Blackburn, and W A. Walker Symposium introduction: metabolic syndrome and the onset of cancer Am. J. Clinical Nutrition, September 1, 2007; 86(3): 817S - 819S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-R. Zhou, L. Li, and W. Pan Dietary soy and tea combinations for prevention of breast and prostate cancers by targeting metabolic syndrome elements in mice Am. J. Clinical Nutrition, September 1, 2007; 86(3): 882S - 888S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. D. Davis Nutritional Interactions: Credentialing of Molecular Targets for Cancer Prevention Experimental Biology and Medicine, February 1, 2007; 232(2): 176 - 183. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C M. Schooling, S. Y. Ho, G. M Leung, G N. Thomas, S. M McGhee, K. H. Mak, and T. H. Lam Diet synergies and mortality--a population-based case-control study of 32 462 Hong Kong Chinese older adults Int. J. Epidemiol., April 1, 2006; 35(2): 418 - 426. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Handayani, L. Rice, Y. Cui, T. A. Medrano, V. G. Samedi, H. V. Baker, N. J. Szabo, and K. T. Shiverick Soy Isoflavones Alter Expression of Genes Associated with Cancer Progression, Including Interleukin-8, in Androgen-Independent PC-3 Human Prostate Cancer Cells J. Nutr., January 1, 2006; 136(1): 75 - 82. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Wallig, K. M. Heinz-Taheny, D. L. Epps, and T. Gossman Synergy among Phytochemicals within Crucifers: Does It Translate into Chemoprotection? J. Nutr., December 1, 2005; 135(12): 2972S - 2977S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D Lambert, J. Hong, G.-y. Yang, J. Liao, and C. S Yang Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations Am. J. Clinical Nutrition, January 1, 2005; 81(1): 284S - 291S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. F. McCarty Targeting Multiple Signaling Pathways as a Strategy for Managing Prostate Cancer: Multifocal Signal Modulation Therapy Integr Cancer Ther, December 1, 2004; 3(4): 349 - 380. [Abstract] [PDF]
|
|
