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Nutrient Metabolism

Dietary -Tocopherol Decreases -Tocotrienol but Not -Tocotrienol Concentration in Rats

Department of Food and Nutrition, Sugiyama Jogakuen University, Chikusa-ku, Nagoya, Japan and ^* Eisai Co. Ltd., Bunkyo-ku, Tokyo, Japan

³To whom correspondence should be addressed. E-mail: kanaey{at}food.sugiyama-u.ac.jp

We previously showed that - and -tocotrienols accumulate in adipose tissue and skin but not in plasma or other tissues of rats fed a tocotrienol-rich fraction extracted from palm oil containing -tocopherol and - and -tocotrienols. To clarify the nature of tocotrienol metabolism, we studied the distribution of - or -tocotrienol in rats fed - or -tocotrienol without -tocopherol, and the effect of -tocopherol on their distribution. Wistar rats (4-wk-old) were fed a diet with 50 mg -tocotrienol/kg alone or with 50 mg -tocopherol/kg in expt. 1, and a diet with 50 mg -tocotrienol/kg alone or with 50 mg -tocopherol/kg in expt. 2, for 8 wk. -Tocotrienol was detected in various tissues and plasma of the rats fed -tocotrienol alone, and the -tocotrienol concentrations in those tissues and plasma decreased (P < 0.05) by the dietary -tocopherol in the rats fed -tocotrienol with -tocopherol. However, -tocotrienol preferentially accumulated in the adipose tissue and skin of the rats fed -tocotrienol alone, and the dietary -tocopherol failed either to decrease (P 0.05) -tocotrienol concentrations in the adipose tissue and skin or to increase (P 0.05) in the urinary excretion of 2,7,8-trimethyl-2(2'-carboxymethyl)-6-hydroxycroman, a metabolite of -tocotrienol, in the rats fed -tocotrienol with -tocopherol. These data suggest that -tocopherol enhances the -tocotrienol metabolism but not the -tocotrienol metabolism in rats.

KEY WORDS: • adipose tissue • rats • skin • tocopherol • tocotrienol • vitamin E

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