QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Ernest, S. Articles by Nadeau, J. H. Search for Related Content PubMed PubMed Citation Articles by Ernest, S. Articles by Nadeau, J. H.

---

Symposium: Improving Human Nutrition through Genomics, Proteomics and Biotechnologies

Nutrigenes, Functional Genomics and Systems Biology¹

Sheila Ernest^*,, Michelle Carter^**, Angela Hosack, David Rosenblatt, Elizabeth Ross^** and Joseph H. Nadeau^*,,2

^* Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, Ohio; Center for Computational Genomics, Case Western Reserve University, Cleveland, Ohio; ^** Laboratory of Neurogenetics and Development, Weill Medical College, Cornell University, New York, NY; and Departments of Human Genetics, Medicine, Pediatrics and Biology, McGill University, Montreal, Quebec, Canada

²To whom correspondence should be addressed. E-mail: jhn4{at}cwru.edu.

Traditionally, the classic reductionist approach attributes functions to individual genes. For instance, this has involved the analysis of motifs or the amino acid sequences of single gene products. It is unclear how the products of particular collections genes act together to provide higher order functionality in health and disease. To address this higher order problem, the function of collections of genes, as opposed to "one gene at a time" has to be studied. Accordingly, a model system is needed to test systems biology. In our studies, we used the homocysteine-folate metabolism as a model system.

KEY WORDS: • systems biology • perturbations • homocysteine-folate metabolism • neural-tube defects • mice