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T Polymorphism in Young Women1,2
Food Science and Human Nutrition Department, University of Florida, and * General Clinical Research Center, University of Florida, Gainesville, FL 32611
3 To whom correspondence should be addressed. E-mail: lbbailey{at}mail.ifas.ufl.edu.
This study was designed to evaluate the effect of the methylenetetrahydrofolate reductase (MTHFR) 677C
T polymorphism on folate and homocysteine response in nonHispanic women consuming a low folate diet followed by a diet providing the Recommended Dietary Allowance (RDA) for folate. Women (aged 20–30 y old) with either the TT (n = 19) or CC (n = 22) MTHFR 677CT genotype participated in a folate depletion-repletion study (7 wk, 115 µg dietary folate equivalents (DFE)/d; 7 wk, 400 µg DFE/d). Overall serum folate decreased (P < 0.0001) during depletion and increased (P < 0.0001) during repletion with lower (P = 0.03) postdepletion serum folate in women with the TT versus CC genotype. Folate status was low (serum folate < 13.6 nmol/L) in more women with the TT (59%) compared with the CC genotype (15%) postdepletion. Red blood cell folate for all subjects decreased during depletion (P < 0.0001) and repletion (P = 0.02) with lower (P = 0.04) red blood cell folate in women with the TT compared with the CC genotype postrepletion. Homocysteine increased (P < 0.0001) for both genotype groups postdepletion and decreased (P = 0.02) postrepletion for the CC genotype group only. Homocysteine concentrations tended to be higher (P = 0.09) in the TT versus CC genotype group postdepletion and postrepletion. These data suggest that the MTHFR 677CT polymorphism negatively affects the folate and homocysteine response in women consuming low folate diets followed by repletion with the RDA. These results may be important when evaluating the impact of the MTHFR 677CT polymorphism in countries in which low folate diets are chronically consumed.
KEY WORDS: • folate • 5'10-methylenetetrahydrofolate reductase • genotype • young women
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