QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Auborn, K. J. Articles by Chiorazzi, N. Search for Related Content PubMed PubMed Citation Articles by Auborn, K. J. Articles by Chiorazzi, N.

---

Nutrition and Aging
Research Communication

Lifespan Is Prolonged in Autoimmune-Prone (NZB/NZW) F1 Mice Fed a Diet Supplemented with Indole-3-Carbinol¹

Karen J. Auborn^*,,**,2, Mei Qi^*, Xiao J. Yan^*, Saul Teichberg^*,, DaZhi Chen^*, Michael P. Madaio and Nicholas Chiorazzi^*,

^* North Shore-Long Island Jewish Research Institute, Manhasset, NY 11030; Department of Otolaryngology, Long Island Jewish Medical Center, The Long Island Campus of Albert Einstein College of Medicine, New Hyde Park, NY 11040; ^** Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461; Laboratories and Pediatrics, North Shore University Hospital and Department of Medicine, North Shore University Hospital, Manhasset, NY 11030; and Renal Electrolyte and Hypertension Division, University of Pennsylvania Medical Center, Philadelphia, PA 19104

²To whom correspondence should be addressed. E-mail: kauborn{at}nshs.edu.

Dietary modulation has the potential to prevent or ameliorate systemic lupus erythematosus (SLE). Indole-3-carbinol (I3C), which is abundant in cruciferous vegetables, was evaluated in a murine model of SLE because of its antiestrogenic activities. Female (NZB x NZW) F1 mice, which develop SLE, were fed an AIN76A diet without or with 0.2 g/kg I3C, starting soon after weaning or at 5 mo of age. At 12 mo of age, 80% of mice fed the I3C-supplemented diet soon after weaning were alive compared with only 10% of controls. When experimental diets were initiated at 5 mo of age, 100% of I3C fed mice and 30% of controls were alive at 12 mo of age. Anti-double-stranded DNA (dsDNA) antibodies developed in all groups, although at several time points, the levels produced in I3C-fed mice were significantly lower. Renal disease (proteinuria, histologic changes, IgG immune complex deposition, subepithelial deposits and diffuse epithelial cell foot process effacement) was more severe in controls with both protocols. The estrogen urinary metabolite ratio of 2- to 16-hydroxyestrone was increased in I3C-fed mice. These findings demonstrate a profound effect of dietary I3C in experimental SLE.

KEY WORDS: • autoimmunity • systemic lupus erythematosus • indole-3-carbinol • anti-DNA antibodies • glomerulonephritis

This article has been cited by other articles:

				Y. Hong, C. Huang, S. Wang, and B. Lin The ethyl acetate extract of alfalfa sprout ameliorates disease severity of autoimmune-prone MRL-lpr/lpr mice Lupus, March 1, 2009; 18(3): 206 - 215. [Abstract] [PDF]

				Y. Hong, T. Wang, C. Huang, W. Cheng, and B. Lin Soy isoflavones supplementation alleviates disease severity in autoimmune-prone MRL-lpr/lpr mice Lupus, September 1, 2008; 17(9): 814 - 821. [Abstract] [PDF]

				J. Cohen-Solal, V Jeganathan, L Hill, D Kawabata, D Pinto-Rodriguez, C Grimaldi, and B Diamond Hormonal regulation of B-cell function and systemic lupus erythematosus Lupus, June 1, 2008; 17(6): 528 - 532. [Abstract] [PDF]

				Z. Yu, B. Mahadevan, C. V. Lohr, K. A. Fischer, M. A. Louderback, S. K. Krueger, C. B. Pereira, D. J. Albershardt, W. M. Baird, G. S. Bailey, et al. Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by the polycyclic aromatic hydrocarbon dibenzo[a,l]pyrene Carcinogenesis, October 1, 2006; 27(10): 2116 - 2123. [Abstract] [Full Text] [PDF]

				K. J. Auborn Can Indole-3-Carbinol-Induced Changes in Cervical Intraepithelial Neoplasia Be Extrapolated to Other Food Components? J. Nutr., October 1, 2006; 136(10): 2676S - 2678S. [Full Text] [PDF]

				J. A. Savino III, J. F. Evans, D. Rabinowitz, K. J. Auborn, and T. H. Carter Multiple, disparate roles for calcium signaling in apoptosis of human prostate and cervical cancer cells exposed to diindolylmethane. Mol. Cancer Ther., March 1, 2006; 5(3): 556 - 563. [Abstract] [Full Text] [PDF]