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© 2003 The American Society for Nutritional Sciences J. Nutr. 133:3571-3576, November 2003

Nutrient Interactions and Toxicity

Egg Sphingomyelin Lowers the Lymphatic Absorption of Cholesterol and {alpha}-Tocopherol in Rats1

Sang K. Noh and Sung I. Koo2,2

Department of Human Nutrition, Kansas State University, Manhattan, KS 66506

2To whom correspondence should be addressed. E-mail: skoo{at}canr.uconn.edu.

Evidence indicates that phosphatidylcholine (PC) inhibits the intestinal absorption of cholesterol (CH) in rats. This study was designed to determine whether sphingomyelin (SM), structurally similar to PC, also inhibits the lymphatic absorption of CH. Sprague-Dawley rats with lymph cannulae were infused at 3.0 mL/h for 8 h via a duodenal catheter with a lipid emulsion [33.3 kBq 14C-CH, 20.7 µmol CH, 451.7 µmol triolein, 3.1 µmol {alpha}-tocopherol ({alpha}TP), 75.4 nmol retinol and 396.0 µmol sodium taurocholate in 24 mL of PBS (pH, 6.5)], without egg SM (SM0) as control, or with 5.0 µmol/h (SM5) or 10.0 µmol/h (SM10). Egg SM lowered the lymphatic absorption of 14C-CH in a dose dependent manner. Likewise, SM lowered the lymphatic absorptions of {alpha}TP and fatty acid (oleic acid), whereas it had no effect on retinol absorption. SM at a high dose (SM10) lowered the lymphatic outputs of both PC and SM, whereas there was no such effect at a lower dose (SM5). These results indicate that luminal egg SM has an inhibitory effect on the intestinal absorption of CH and other lipids of relatively high hydrophobicity. Our findings suggest that SM, if ingested in sufficient amounts, may inhibit the intestinal absorption of dietary lipids including cholesterol and {alpha}TP.

KEY WORDS: • sphingomyelin • {alpha}-tocopherol • cholesterol • intestinal absorption • rats • retinol




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