QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Tai, E S. Articles by Ordovas, J. M. Search for Related Content PubMed PubMed Citation Articles by Tai, E S. Articles by Ordovas, J. M.

---

Nutrient-Gene Interactions

Dietary Fat Interacts with the -514C>T Polymorphism in the Hepatic Lipase Gene Promoter on Plasma Lipid Profiles in a Multiethnic Asian Population: The 1998 Singapore National Health Survey^1,2

E Shyong Tai, Dolores Corella^*, Mabel Deurenberg-Yap, Jeffery Cutter^**, Suok Kai Chew^**, Chee Eng Tan and Jose M. Ordovas^,3

Department of Endocrinology, Singapore General Hospital, Singapore 169608; ^* Genetic and Molecular Epidemiology Unit, Department of Preventive Medicine, University of Valencia, 46010-Valencia, Spain; Research and Information Management Division, Health Promotion Board, Singapore 168937; ^** Epidemiology and Disease Control Division, Ministry of Health, College of Medicine Building, Singapore 169854; Nutrition and Genomics Laboratory, JM-U.S. Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111

³To whom correspondence should be addressed. E-mail: jose.ordovas{at}tufts.edu.

We have previously reported an interaction between -514C>T polymorphism at the hepatic lipase (HL) gene and dietary fat on high-density lipoprotein-cholesterol (HDL-C) metabolism in a representative sample of white subjects participating in the Framingham Heart Study. Replication of these findings in other populations will provide proof for the relevance and consistency of this marker as a tool for risk assessment and more personalized cardiovascular disease prevention. Therefore, we examined this gene-nutrient interaction in a representative sample of Singaporeans (1324 Chinese, 471 Malays and 375 Asian Indians) whose dietary fat intake was recorded by a validated questionnaire. When no stratification by fat intake was considered, the T allele was associated with higher plasma HDL-C concentrations (P = 0.001), higher triglyceride (TG) concentrations (P = 0.001) and higher HDL-C/TG ratios (P = 0.041). We found a highly significant interaction (P = 0.001) between polymorphism and fat intake in determining TG concentration and the HDL-C/TG ratio (P = 0.001) in the overall sample even after adjustment for potential confounders. Thus, TT subjects showed higher TG concentrations only when fat intake supplied >30% of total energy. This interaction was also found when fat intake was considered as continuous (P = 0.035). Moreover, in the upper tertile of fat intake, TT subjects had 45% more TG than CC individuals (P < 0.01). For HDL-C concentration, the gene-diet interaction was significant (P = 0.015) only in subjects of Indian origin. In conclusion, our results indicate that there are differences in the association of -514C>T polymorphism with plasma lipids according to dietary intake and ethnic background. Specifically, the TT genotype is associated with a more atherogenic lipid profile when subjects consume diets with a fat content > 30%.

KEY WORDS: • Dietary fat • hepatic lipase • gene x nutrient interaction • cardiovascular risk.

This article has been cited by other articles:

				P. Riestra, L. Lopez-Simon, H. Ortega, L. Gorgojo, J. M. Martin-Moreno, S. Schoppen, M. de Oya, and C. Garces Fat Intake Influences the Effect of the Hepatic Lipase C-514T Polymorphism on HDL-Cholesterol Levels in Children Experimental Biology and Medicine, July 1, 2009; 234(7): 744 - 749. [Abstract] [Full Text] [PDF]

				L. Baum, M. C.Y. Ng, W.-Y. So, V. K.L. Lam, Y. Wang, E. Poon, B. Tomlinson, S. Cheng, K. Lindpaintner, and J. C.N. Chan Effect of Hepatic Lipase -514C->T Polymorphism and Its Interactions With Apolipoprotein C3 -482C->T and Apolipoprotein E Exon 4 Polymorphisms on the Risk of Nephropathy in Chinese Type 2 Diabetic Patients Diabetes Care, July 1, 2005; 28(7): 1704 - 1709. [Abstract] [Full Text] [PDF]

				N. Stefan, S. Schafer, F. Machicao, J. Machann, F. Schick, C. D. Claussen, M. Stumvoll, H.-U. Haring, and A. Fritsche Liver Fat and Insulin Resistance Are Independently Associated with the -514C>T Polymorphism of the Hepatic Lipase Gene J. Clin. Endocrinol. Metab., July 1, 2005; 90(7): 4238 - 4243. [Abstract] [Full Text] [PDF]

				J. S Fisler and C. H Warden Dietary fat and genotype: toward individualized prescriptions for lifestyle changes Am. J. Clinical Nutrition, June 1, 2005; 81(6): 1255 - 1256. [Full Text] [PDF]

				C. Zhang, R. Lopez-Ridaura, E. B Rimm, N. Rifai, D. J Hunter, and F. B Hu Interactions between the -514C->T polymorphism of the hepatic lipase gene and lifestyle factors in relation to HDL concentrations among US diabetic men Am. J. Clinical Nutrition, June 1, 2005; 81(6): 1429 - 1435. [Abstract] [Full Text] [PDF]

				T. H. Ehrich, T. Hrbek, J. P. Kenney-Hunt, L. S. Pletscher, B. Wang, C. F. Semenkovich, and J. M. Cheverud Fine-Mapping Gene-by-Diet Interactions on Chromosome 13 in a LG/J x SM/J Murine Model of Obesity Diabetes, June 1, 2005; 54(6): 1863 - 1872. [Abstract] [Full Text] [PDF]

				T. E. Moffitt, A. Caspi, and M. Rutter Strategy for Investigating Interactions Between Measured Genes and Measured Environments Arch Gen Psychiatry, May 1, 2005; 62(5): 473 - 481. [Abstract] [Full Text] [PDF]