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American Health Foundation Cancer Center, Institute for Cancer Prevention, Valhalla, NY 10595
2To whom correspondence should be addressed. E-mail: chungahf{at}aol.comfchung@ifcp.us.
The role of tea in protection against cancer has been supported by ample evidence from studies in cell culture and animal models. However, epidemiological studies have generated inconsistent results, some of which associated tea with reduced risk of cancer, whereas others found that tea lacks protective activity against certain human cancers. These results raise questions about the actual role of tea in human cancer that needs to be addressed. This article is intended to provide a better perspective on this controversy by summarizing the laboratory studies in animals and humans with emphasis on animal tumor bioassays on skin, lung, mammary glands and colon, and the molecular and cellular mechanisms affected by tea. Finally, a recent small pilot intervention study with green tea in smokers is presented.
KEY WORDS: • green tea • black tea • lung cancer • oral cancer • smokers • antioxidant
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