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Nutrient Metabolism

Dietary Conjugated Linoleic Acids as Free Fatty Acids and Triacylglycerols Similarly Affect Body Composition and Energy Balance in Mice¹

A. H. M. Terpstra², M. Javadi^*, A. C. Beynen^*, S. Kocsis, A. E. Lankhorst, A. G. Lemmens and I. C. M. Mohede^**

Department of Laboratory Animal Science, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 2, 3584 CM Utrecht, The Netherlands; ^* Department of Nutrition, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 12 3584 CM Utrecht, The Netherlands; Department of Physiology, Faculty of Veterinary Medicine, Yalelaan 1, 3584 CM Utrecht, The Netherlands; and ^** Loders Croklaan b.v., Hogeweg 1, 1521 AZ Wormerveer, The Netherlands

²To whom correspondence should be addressed. E-mail: a.h.m. terpstra{at}las.vet.uu.nl.

The objective of this study was to compare the effects of conjugated linoleic acid (CLA) as triacylglycerols (TAG) or free fatty acids (FFA) on body composition and energy balance in mice. We fed four groups of 5-wk-old Balb-C mice (n = 9) semipurified diets containing either CLA (0.5 g CLA/100 g of diet) or high oleic sunflower oil (HOSF) in the form of FFA or TAG for 42 d. Body composition was determined and the energy in the carcasses, excreta and food was measured in a bomb calorimeter. The amount of body fat was 4.72 ± 0.95 g (17.9 ± 2.8%) in the HOSF-FFA group, 2.36 ± 0.29 g (9.4 ± 1.0%) in the CLA-FFA mice (mean ± SD, P < 0.05), 4.76 ± 0.74 g (18.2 ± 2.2%) in the HOSF-TAG group and 2.32 ± 0.38 g (9.3 ± 1.1%) in the CLA-TAG mice (P < 0.05). The percentage of energy intake that was stored in the body was 3.5 ± 1.2% in the HOSF-FFA group, 0.6 ± 0.3% in the CLA-FFA group (P < 0.05), 3.5 ± 1.1% in the HOSF-TAG group and 0.5 ± 0.4 in the CLA-TAG mice (P < 0.05). Conversely, the percentage of energy intake that was expended as heat was 89.4 ± 1.2% in the HOSF-FFA group, 92.4 ± 0.8% in the CLA-FFA mice (P < 0.05), 89.47 ± 1.23% in the HOSF-TAG group and 92.2 ± 0.4% in the CLA-TAG group (P < 0.05). Thus, CLA in the form of FFA or TAG had similar effects on body composition and energy balance.

KEY WORDS: • conjugated linoleic acid • mice • body composition

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