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*
Departamento de Nutrición y Departamento de Técnicas Instrumentales, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain and
Servicio de Geriatría, Hospital de Cantoblanco-Gregorio Marañon, Madrid, Spain
1To whom correspondence should be addressed. E-mail: rortega{at}farm.ucm.es.
The aim of this study was to examine associations between vitamin E status and cognitive performance in elderly people. The study subjects were a group of 34 men and 86 women, aged 65–91 y, who were free of significant cognitive impairment. Dietary intake was monitored using a "weighed food record" for 5 consecutive days including a Sunday. Serum levels of 
-tocopherol and cholesterol were determined by HPLC and colorimetric methods, respectively. The cognitive capacity of subjects was tested using the Pfeiffer’s Mental Status Questionnaire (PMSQ). Subjects with vitamin E intakes lower than 50% of those recommended had higher PMSQ scores, demonstrating a greater number of errors in comparison to participants with a greater intake of the vitamin (0.91 ± 1.22 vs. 0.47 ± 0.60, respectively, P < 0.05). Subjects who made no errors in the PMSQ test had significantly higher serum -tocopherol concentrations (19.7 ± 8.6 µmol/L in men and 20.0 ± 8.4 µmol/L in women) and -tocopherol/cholesterol ratios (3.5 ± 2.0 µmol/mmol in men 2.9 ± 1.4 µmol/mmol in women) compared with those who made errors (-tocopherol 15.1 ± 5.6 µmol/L in men and 14.9 ± 6.1 µmol/L in women; -tocopherol/cholesterol ratio 2.4 ± 0.8 and 2.3 ± 1.3 µmol/mmol in men and women, respectively). This study shows there to be a relationship between vitamin E status and cognitive function, and that vitamin E status could be improved in this population of elderly individuals.
KEY WORDS: • vitamin E • elderly people • -tocopherol • intake • cognitive function
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