QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Tanumihardjo, S. A. Search for Related Content PubMed PubMed Citation Articles by Tanumihardjo, S. A. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Medline Plus Health Information Dietary Supplements Pregnancy Hazardous Substances DB IRON VITAMIN A

---

Community and International Nutrition
Research Communication

Vitamin A and Iron Status Are Improved by Vitamin A and Iron Supplementation in Pregnant Indonesian Women^{1 ,2}

Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI 53706-1571

³To whom correspondence should be addressed. E-mail: sherry{at}nutrisci.wisc.edu.

In Indonesia, deficiencies of vitamin A and iron are of public health concern during pregnancy. We sought to determine the effects of vitamin A and iron supplementation on the vitamin A and iron status of pregnant Indonesian women. The women (n = 27) were randomly assigned to four groups. The modified relative dose response (MRDR) test for vitamin A status and hemoglobin, hematocrit and ferritin values were determined at baseline. Thereafter, daily supplements were administered: placebo [Pl] (n = 7), 8.4 µmol vitamin A [A] (n = 7), 1.07 mmol iron [Fe] (n = 5), and 8.4 µmol vitamin A plus 1.07 mmol iron [A + Fe] (n = 8). Post-treatment tests were performed after 8 wk. The MRDR value was reduced, i.e., vitamin A status improved, more markedly by the combination of vitamin A and iron than by either nutrient alone (P = 0.034). The decrease in the MRDR relative to baseline was significant in the A + Fe group (P = 0.008). Iron status was also significantly improved in these women (P < 0.05) with both iron and vitamin A supplementation. The mechanism of the enhancing effect of iron on the vitamin A–induced reduction in the MRDR is not known.

KEY WORDS: • vitamin A status assessment • modified relative dose response • pregnant women • iron status • Indonesia

This article has been cited by other articles:

				L. W. Tengco, P. Rayco-Solon, J. A. Solon, J. N. Sarol Jr., and F. S. Solon Determinants of Anemia among Preschool Children in the Philippines J. Am. Coll. Nutr., April 1, 2008; 27(2): 229 - 243. [Abstract] [Full Text] [PDF]

				R. L Surles, J. P Mills, A. R Valentine, and S. A Tanumihardjo One-time graded doses of vitamin A to weanling piglets enhance hepatic retinol but do not always prevent vitamin A deficiency Am. J. Clinical Nutrition, October 1, 2007; 86(4): 1045 - 1053. [Abstract] [Full Text] [PDF]

				J. M Graham, M. J Haskell, P. Pandey, R. K Shrestha, K. H Brown, and L. H Allen Supplementation with iron and riboflavin enhances dark adaptation response to vitamin A-fortified rice in iron-deficient, pregnant, nightblind Nepali women Am. J. Clinical Nutrition, May 1, 2007; 85(5): 1375 - 1384. [Abstract] [Full Text] [PDF]

				S. A Tanumihardjo and B. A Underwood Utility of the relative-dose-response and modified-relative-dose-response tests as population indicators of vitamin A status Am. J. Clinical Nutrition, November 1, 2005; 82(5): 1135 - 1137. [Full Text] [PDF]

				H. Verhoef and C. E West Validity of the relative-dose-response test and the modified-relative-dose-response test as indicators of vitamin A stores in liver Am. J. Clinical Nutrition, April 1, 2005; 81(4): 835 - 839. [Abstract] [Full Text] [PDF]

				S. A. Tanumihardjo Assessing Vitamin A Status: Past, Present and Future J. Nutr., January 1, 2004; 134(1): 290S - 293. [Abstract] [Full Text] [PDF]