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Human Nutrition and Metabolism
Research Communication

A Single 60-mg Iron Dose Decreases Zinc Absorption in Lactating Women^{1 ,2}

Carolyn S. Chung, David A. Nagey^*, Claude Veillon, Kristine Y. Patterson, Robert T. Jackson and Phylis B. Moser-Veillon³

Department of Nutrition and Food Science, University of Maryland, College Park, MD; ^* Department of Gynecology and Obstetrics, The Johns Hopkins University, Baltimore, MD; Beltsville Human Nutrition Research Center, U.S. Department of Agriculture, Beltsville, MD

³To whom correspondence should be addressed. E-mail: pv6{at}umail.umd.edu.

This study determined whether a single 60-mg dose of ferrous sulfate interferes with fractional zinc absorption (FZA) at 7–9 wk of lactation. In a crossover design, 5 exclusively breast-feeding women were given either a single 60-mg iron supplement or no supplement. FZA was measured by analyzing zinc stable isotope tracers (⁷⁰Zn and ⁶⁷Zn) in urine samples collected for 7 d after isotope dosing. A 0.7-µmol intravenous (IV) infusion of ⁷⁰Zn as ZnCl₂ in saline was followed by a 0.03-mmol oral dose of ⁶⁷Zn as ZnCl₂ given with a standardized meal. After a 7-d wash-out period, the supplement given was reversed and a second FZA measurement was taken. FZA was calculated from isotopic enrichments in urine measured by inductively coupled plasma mass spectrometry. Hemoglobin, plasma ferritin and transferrin receptor, and plasma 5'-nucleotidase, plasma zinc and erythrocyte zinc did not differ before the two measurements of zinc absorption. When women were given a single iron supplement, FZA was significantly lower, 21.7 ± 1.7% compared with 26.9 ± 2.6% when no supplement was given (P = 0.032). A single 60-mg iron dose significantly decreases FZA during early lactation.

KEY WORDS: • zinc absorption • iron supplementation • lactation • stable isotopes

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