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Nutrition and Aging

Short-Term Folate, Vitamin B-12 or Vitamin B-6 Supplementation Slightly Affects Memory Performance But Not Mood in Women of Various Ages^{1 ,2}

Commonwealth Scientific and Industrial Research Organisation, Health Sciences and Nutrition, Kintore Avenue, Adelaide, 5000 Australia

³To whom correspondence should be addressed. E-mail: eva.calvaresi{at}csiro.au.

Based on research demonstrating associations between folate, B-12 and B-6 vitamins and cognition and mood, we investigated the effects of short-term supplementation in 211 healthy younger, middle-aged and older women who took either 750 µg of folate, 15 µg of vitamin B-12, 75 mg of vitamin B-6 or a placebo daily for 35 d. In addition, we examined associations between dietary intake of these vitamins and cognition and mood. Usual dietary intake status was estimated using a retrospective, self-report, quantified food frequency questionnaire. Participants completed alternate forms of standardized tests of cognitive processing resources, memory, executive function, verbal ability and self-report mood measures before and after supplementation. Supplementation had a significant positive effect on some measures of memory performance only, and no effect on mood. Dietary intake status was associated with speed of processing, recall and recognition and verbal ability.

KEY WORDS: • folate • vitamin B-12 • vitamin B-6 • mood • cognition • humans

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