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Nutrient Interactions and Toxicity

Green Tea Extract Inhibits the Lymphatic Absorption of Cholesterol and -Tocopherol in Ovariectomized Rats^{1 ,2}

Department of Human Nutrition, Kansas State University, Manhattan, KS 66506

³To whom correspondence should be addressed. E-mail: koo{at}humec.ksu.edu

Evidence indicates that green tea consumption lowers the serum level of cholesterol (CH). This study was conducted to determine whether green tea lowers the intestinal absorption of CH and other lipids in ovariectomized (OX) rats. OX rats with lymph duct cannulae were infused at 3.0 mL/h for 8 h via an intraduodenal catheter with a lipid emulsion containing ¹⁴C-cholesterol (¹⁴C-CH) and -tocopherol (TP) without (GT0) or with green tea extract standardized to 42.9 mg (GT1) or 120.5 mg (GT2) of total catechins in PBS (pH 6.5). Green tea extracts dose-dependently reduced (P < 0.05) the lymphatic absorption of ¹⁴C-CH. The cumulative absorptions of ¹⁴C-CH in rats infused with GT0, GT1 and GT2 were 36.3 ± 1.1, 20.7 ± 4.3 and 4.8 ± 4.1% dose, respectively. The percentage distribution of esterified CH did not differ between rats infused with GT0 and GT1 (80.2 ± 2.3% vs. 79.0 ± 1.7%), but was significantly lower in those given GT2 (69.1 ± 6.8%). The absorption of TP also was significantly reduced by GT1 (736.5 ± 204.9 nmol, 20.8 ± 5.8% dose) and GT2 (281.0 ± 190.8 nmol, 7.9 ± 5.4% dose) compared with GT0 (1048.8 ± 174.9 nmol, 29.6 ± 4.9% dose). The absorption of fat was significantly increased by GT1 (862.6 ± 151.1 µmol) but lowered by GT2 (557.9 ± 252.2 µmol) relative to GT0 (717.7 ± 39.1 µmol). The findings provide direct evidence that green tea has a profound inhibitory effect on the intestinal absorption of CH and TP in OX rats. Whether the inhibitory effect of green tea extract is attributable to a specific catechin(s) and other components in green tea remains to be determined.

KEY WORDS: • green tea • catechins • cholesterol • absorption • rats • -tocopherol

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