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Department of Nutrition, The Pennsylvania State University, University Park, PA 16802
2To whom correspondence should be addressed. E-mail: acr6{at}psu.edu.
Lecithin:retinol acyltransferase (LRAT), a retinol esterifying enzyme, plays a major role in the metabolism and storage of vitamin A in several animal tissues. Groups of vitamin A (VA)-adequate (control) and VA-deficient rats were treated with vehicle or 5 mg of all-trans-retinoic acid (RA); an additional group of VA-deficient rats were fed 100 µg of RA. In control rats, lung LRAT mRNA and LRAT specific activity were 
50% of the levels expressed in the liver. In the lung of VA-deficient rats, LRAT mRNA and specific activity levels were <10% of those in the control group. Treatment of VA-deficient rats with 100 µg RA increased lung LRAT mRNA (P < 0.005) and specific activity (P < 0.0001), and treatment with 5 mg of RA increased LRAT mRNA level and specific activity more than 15- and 6-fold above those in control lung, respectively (both P 
0.001). The lung tissue of VA-adequate rats contained retinyl ester (3 nmol/g tissue), whereas none was detected in the lung tissue of VA-deficient rats. These results show that LRAT expression and vitamin A storage are regulated by vitamin A status and by treatment with all-trans-RA in the adult lung. These results suggest that the regulated storage of vitamin A may be important for maintaining the integrity and physiologic functions of the lung.
KEY WORDS: • retinyl ester • retinyl palmitate • vitamin A deficiency • rats
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