QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Murray-Kolb, L. E. Articles by Beard, J. L. Search for Related Content PubMed PubMed Citation Articles by Murray-Kolb, L. E. Articles by Beard, J. L.

---

Nutrient Requirements/DOCTOPIC>
Research Communication

Transgenic Rice Is a Source of Iron for Iron-Depleted Rats¹

Laura E. Murray-Kolb, Fumio Takaiwa^*, Fumiyuki Goto^*, Toshihiro Yoshihara, Elizabeth C. Theil^** and John L. Beard²

Department of Nutrition, The Pennsylvania State University, University Park, PA; ^* Department of Plant Biotechnology, National Institute of Agrobiological Sciences (NIAS), Kannondai 2–1-2, Tsukuba, Ibaraki 305-8602, Japan; Department of Bio-Science, Central Research Institute of Electric Power Industry (CRIEPI), 1646 Abiko, Chiba 277-1194, Japan; and ^** CHORI (Children’s Hospital Oakland Research Institute), Oakland, CA

²To whom correspondence should be addressed. E-mail: its{at}psu.edu.

Iron deficiency is one of the most prevalent nutrient deficiencies in the world. A sustainable solution to dietary iron deficiency may be achieved in part by increasing bioavailable iron in seeds used for foods such as rice. Because ferritin is used as a natural source of iron in the early development of humans, other animals and plants, the bioavailability of iron in rice seeds, provided in amounts equal to ferrous sulfate, and in transgenic rice with ferritin was tested in iron-deficient rats. A standard hemoglobin (Hb) repletion bioassay was used with rats made anemic followed by complete diets containing equivalent amounts of iron as FeSO₄ or one of three different bioengineered rice varieties (Kitaake and two transgenic derivatives with ferritin targeted to the seed, FK11 and FK22). Rice diets were as effective as the FeSO₄ diet in replenishing hematocrit, Hb concentration and liver iron concentrations. These data suggest that Mendelian and biotechnological approaches to manipulating ferritin expression of seed iron in rice may contribute to a sustainable solution to global problems of iron deficiency.

KEY WORDS: • ferritin • iron deficiency • rats • rice

This article has been cited by other articles:

				B. Lonnerdal, A. Bryant, X. Liu, and E. C Theil Iron absorption from soybean ferritin in nonanemic women Am. J. Clinical Nutrition, January 1, 2006; 83(1): 103 - 107. [Abstract] [Full Text] [PDF]

				B. Lonnerdal Genetically Modified Plants for Improved Trace Element Nutrition J. Nutr., May 1, 2003; 133(5): 1490S - 1493. [Abstract] [Full Text] [PDF]

				E. C. Theil Ferritin: At the Crossroads of Iron and Oxygen Metabolism J. Nutr., May 1, 2003; 133(5): 1549S - 1553. [Abstract] [Full Text] [PDF]