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Symposium: Can Lutein Protect Against Chronic Disease?

Possible Biologic Mechanisms for a Protective Role of Xanthophylls¹

Department of Biochemistry, School of Medicine, U.S. Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111-1837

²To whom correspondence should be addressed. E-mail: norman.krinsky{at}tufts.edu.

This contribution surveys the evidence linking the presence of the two xanthophylls, lutein and zeaxanthin, to a protective role in the macular region of the retina. Although the evidence is still associative in nature, it is biologically plausible, and may be resolved with additional intervention trials.

KEY WORDS: • lutein • zeaxanthin • age-related macular degeneration • antioxidation

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