Journal of Nutrition LabDiet, Your World of Nutritional Answers

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
 QUICK SEARCH:   [advanced]


     


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mayne, S. T.
Right arrow Articles by Navarro, S. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mayne, S. T.
Right arrow Articles by Navarro, S. A.

© 2002 The American Society for Nutritional Sciences J. Nutr. 132:3467S-3470S, November 2002


Supplement: International Research Conference on Food, Nutrition & Cancer

Diet, Obesity and Reflux in the Etiology of Adenocarcinomas of the Esophagus and Gastric Cardia in Humans1 ,2

Susan T. Mayne3 and Stephanie A. Navarro

Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT

3To whom correspondence should be addressed. E-mail: susan.mayne{at}yale.edu.

Incidence rates for esophageal adenocarcinoma have increased >350% since the mid-1970s. Rates for gastric cardia adenocarcinoma have also increased, although less steeply. This led to the initiation of large population-based case-control studies, particularly in the United States and Sweden, aimed at identifying risk factors for these cancers. Results have been emerging from these studies, with the consistent finding that obesity and gastroesophageal reflux disease are important risk factors for these cancers. Analyses of dietary factors are also available and indicate that diets high in total fat, saturated fat and cholesterol are associated with an increased risk of these cancers, whereas several nutrients, particularly those found in plant foods (fiber, vitamin C, ß-carotene, folate), are associated with a reduced risk. Considering the incidence trends of these cancers and the trends in the prevalence of risk factors, the increasing prevalence of obesity in the United States likely accounts for some of the increased incidence. However, other contributors to the increasing trends have been suggested and will be discussed. Because diet, obesity and gastroesophageal reflux disease may not act independently in contributing to these cancers, current research is attempting to identify associations between the three risk factors and potential mechanisms of action to better understand the etiology of these cancers.


KEY WORDS: • obesity • reflux • diet • esophageal neoplasms • gastric neoplasms




This article has been cited by other articles:


Home page
Am J EpidemiolHome page
A. Kubo, T. R. Levin, G. Block, G. J. Rumore, C. P. Quesenberry Jr, P. Buffler, and D. A. Corley
Dietary Patterns and the Risk of Barrett's Esophagus
Am. J. Epidemiol., April 1, 2008; 167(7): 839 - 846.
[Abstract] [Full Text] [PDF]


Home page
Ann. Thorac. Surg.Home page
C. N. Scipione, A. C. Chang, A. Pickens, C. L. Lau, and M. B. Orringer
Transhiatal Esophagectomy in the Profoundly Obese: Implications and Experience
Ann. Thorac. Surg., August 1, 2007; 84(2): 376 - 383.
[Abstract] [Full Text] [PDF]


Home page
CarcinogenesisHome page
M. Jenab, E. Riboli, P. Ferrari, J. Sabate, N. Slimani, T. Norat, M. Friesen, A. Tjonneland, A. Olsen, K. Overvad, et al.
Plasma and dietary vitamin C levels and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)
Carcinogenesis, November 1, 2006; 27(11): 2250 - 2257.
[Abstract] [Full Text] [PDF]


Home page
Cancer Epidemiol. Biomarkers Prev.Home page
J. J. Kelly, A. P. Lanier, S. Alberts, and C. L. Wiggins
Differences in Cancer Incidence among Indians in Alaska and New Mexico and U.S. Whites, 1993-2002.
Cancer Epidemiol. Biomarkers Prev., August 1, 2006; 15(8): 1515 - 1519.
[Abstract] [Full Text] [PDF]


Home page
JNCI J Natl Cancer InstHome page
C. A. Gonzalez, P. Jakszyn, G. Pera, A. Agudo, S. Bingham, D. Palli, P. Ferrari, H. Boeing, G. del Giudice, M. Plebani, et al.
Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation Into Cancer and Nutrition (EPIC).
J Natl Cancer Inst, March 1, 2006; 98(5): 345 - 354.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Gastrointest. Liver Physiol.Home page
K. J. Maurer, A. B. Rogers, Z. Ge, A. J. Wiese, M. C. Carey, and J. G. Fox
Helicobacter pylori and cholesterol gallstone formation in C57L/J mice: a prospective study
Am J Physiol Gastrointest Liver Physiol, January 1, 2006; 290(1): G175 - G182.
[Abstract] [Full Text] [PDF]


Home page
CarcinogenesisHome page
Z. Zhang, Y. Xu, J. Zhou, X. Wang, L. Wang, X. Hu, J. Guo, Q. Wei, and H. Shen
Polymorphisms of thymidylate synthase in the 5'- and 3'-untranslated regions associated with risk of gastric cancer in South China: a case-control analysis
Carcinogenesis, October 1, 2005; 26(10): 1764 - 1769.
[Abstract] [Full Text] [PDF]


Home page
GutHome page
J Lagergren
Adenocarcinoma of oesophagus: what exactly is the size of the problem and who is at risk?
Gut, March 1, 2005; 54(suppl_1): i1 - i5.
[Abstract] [Full Text] [PDF]




Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Copyright © 2002 by American Society for Nutrition