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Nutrient Metabolism – Research Communication

Net Portal Absorption of Enterally Fed -Ketoglutarate Is Limited in Young Pigs^{1 ,2}

Barry D. Lambert, Barbara Stoll, Harri Niinikoski, Stefan Pierzynowski^*, and Douglas G. Burrin³

U.S. Department of Agriculture/ARS Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030; ^* Gramineer Int. AB, Ideon, SE-223 70 Lund, Sweden; and Lund University, Department of Animal Physiology, SE-233 63 Lund, Sweden

³To whom correspondence and reprint requests should be addressed. E-mail: dburrin{at}bcm.tmc.edu.

Our aim was to quantify the intestinal metabolic fate of dietary -ketoglutarate (AKG). Female pigs (n = 6; 21 d old) were implanted with arterial, venous, portal and gastric catheters and an ultrasonic portal flow probe and fed a corn and soybean meal–based diet. On the day of the experiment, the pigs received a 4-h intragastric infusion of sodium AKG at a rate equivalent to 0, 2.5, 5 or 10% of dietary intake. The net portal AKG balance of the control and 2.5% treatments did not differ and were not different from zero. However, the net portal AKG balance of both the 5 [163 µmol/(kg · h)] and 10% [159 µmol/(kg · h)] treatments were greater (P < 0.05) than the control. Despite significant net AKG absorption at the 5 and 10% levels, the net portal appearance represented only 10.8 and 6.7%, respectively, of the enteral input. The net portal appearances of glutamate, glutamine, ammonia and the branched-chain amino acids were not affected by dietary AKG level. We conclude that the absorption of dietary AKG is limited in young pigs and does not change the net portal balance of amino acids or ammonia.

KEY WORDS: • glutamate • ammonia • glutamate dehydrogenase • dicarboxylic acid transport • pigs

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