QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Fritz, W. A. Articles by Lamartiniere, C. A. Search for Related Content PubMed PubMed Citation Articles by Fritz, W. A. Articles by Lamartiniere, C. A.

---

Biochemical and Molecular Actions of Nutrients

Genistein Alters Growth but Is Not Toxic to the Rat Prostate^{1 ,2}

Wayne A. Fritz^*, Isam-Eldin Eltoum, Michelle S. Cotroneo^* and Coral A. Lamartiniere^*3

^* Department of Pharmacology and Toxicology and the Comprehensive Cancer Center, and Department of Pathology, University of Alabama at Birmingham, AL 35294

³To whom correspondence should be addressed. E-mail: coral.lamartiniere{at}ccc.uab.edu.

The mortality of clinical prostate cancer is lower in Asian populations than in American or European men. Asian men typically consume more soy than their Western counterparts, leading to the investigation of individual components, particularly phytoestrogens, as protective factors against prostate cancer. Genistein, the predominant isoflavone in soy, has been reported to reduce the incidence of prostate cancer in animal models, but the underlying biological action remains to be elucidated. The purpose of this investigation was to identify the effects of the phytoestrogen, genistein and the synthetic estrogen diethylstilbestrol (DES), as a control, on development and function of the rat dorsolateral prostate (DLP) when given in the diet. The effects of testosterone and dihydrotestosterone (DHT) injections were also tested. Analysis of individual lobes of the DLP revealed that 1000 mg/kg, but not 250 mg/kg, of a genistein AIN-76A diet slightly reduced lateral prostate type 1 (LP1) bud perimeter. However, expression of the secretory dorsal protein 1 (DP1) and 5-reductase type II activity were not altered in the prostate. This suggested that prostate differentiation, and not toxicity, had occurred. DES in the diet reduced and testosterone injections elevated relative prostate weights and perimeters of the dorsal, LP1, lateral prostate type 2 and DP1 expression. DHT increased relative prostate weights but did not significantly increase individual lobe perimeter. Unlike DES, maximally tolerated doses of genistein in the diet were not toxic to the rat prostate.

KEY WORDS: • genistein • diethylstilbesterol • prostate • 5-reductase • morphology

This article has been cited by other articles:

				A. A Grippo, K. Capps, B. Rougeau, and B. J Gurley Analysis of Flavonoid Phytoestrogens in Botanical and Ephedra-Containing Dietary Supplements Ann. Pharmacother., September 1, 2007; 41(9): 1375 - 1382. [Abstract] [Full Text] [PDF]

				S. Goodin, F. Shen, W. J. Shih, N. Dave, M. P. Kane, P. Medina, G. H. Lambert, J. Aisner, M. Gallo, and R. S. DiPaola Clinical and Biological Activity of Soy Protein Powder Supplementation in Healthy Male Volunteers Cancer Epidemiol. Biomarkers Prev., April 1, 2007; 16(4): 829 - 833. [Abstract] [Full Text] [PDF]

				G. G. Hillman, Y. Wang, O. Kucuk, M. Che, D. R. Doerge, M. Yudelev, M. C. Joiner, B. Marples, J. D. Forman, and F. H. Sarkar Genistein potentiates inhibition of tumor growth by radiation in a prostate cancer orthotopic model Mol. Cancer Ther., October 1, 2004; 3(10): 1271 - 1279. [Abstract] [Full Text] [PDF]

				W. A. Fritz, M. S. Cotroneo, J. Wang, I.-E. Eltoum, and C. A. Lamartiniere Dietary Diethylstilbestrol but Not Genistein Adversely Affects Rat Testicular Development J. Nutr., July 1, 2003; 133(7): 2287 - 2293. [Abstract] [Full Text] [PDF]