![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
University of Western Australia Department of Medicine and HeartSearch, Royal Perth Hospital, Perth, WA 6001, Australia
Prospective studies suggest that tea may protect against cardiovascular disease. A potential mechanism for such an effect involves inhibition of lipid peroxidation by polyphenolic antioxidants derived from tea. Our objective was to determine whether regular ingestion of tea could inhibit in vivo lipid peroxidation. Two controlled intervention studies assessed the effects of regular ingestion of tea on lipid peroxidation determined by measurement of urinary F2-isoprostane excretion. Study 1: The effects of 1000 mL/d of green tea and black tea were compared with hot water containing caffeine in 13 subjects with elevated blood pressure using a randomized 3-period (7 d each) crossover design. Study 2: The effects of 1250 mL/d of black tea were compared with hot water in 22 subjects with mildly raised serum total cholesterol concentrations using a randomized 2-period (4 wk each) crossover design. F2-isoprostane excretion was not altered after regular ingestion of green tea (273 ± 48 pmol/mmol creatinine) or black tea (274 ± 39 pmol/mmol creatinine) in comparison with hot water (263 ± 47 pmol/mmol creatinine; Study 1), or by regular ingestion of black tea (334 ± 71 pmol/mmol creatinine) in comparison with hot water (355 ± 75 pmol/mmol creatinine; Study 2). These results do not support the suggestion that polyphenolic antioxidants derived from tea inhibit in vivo lipid peroxidation.
KEY WORDS: • tea • antioxidant • oxidative stress • isoprostanes • lipid peroxidation • humans
This article has been cited by other articles:
|
|
 |
|
  W. M. Loke, J. M Hodgson, J. M Proudfoot, A. J McKinley, I. B Puddey, and K. D Croft Pure dietary flavonoids quercetin and (-)-epicatechin augment nitric oxide products and reduce endothelin-1 acutely in healthy men Am. J. Clinical Nutrition, October 1, 2008; 88(4): 1018 - 1025. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kuriyama The Relation between Green Tea Consumption and Cardiovascular Disease as Evidenced by Epidemiological Studies J. Nutr., August 1, 2008; 138(8): 1548S - 1553S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Shenouda and J. A. Vita Effects of Flavonoid-Containing Beverages and EGCG on Endothelial Function J. Am. Coll. Nutr., August 1, 2007; 26(4): 366S - 372S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Taubert, R. Roesen, and E. Schomig Effect of Cocoa and Tea Intake on Blood Pressure: A Meta-analysis Arch Intern Med, April 9, 2007; 167(7): 626 - 634. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Wang, S. K. Noh, and S. I. Koo Epigallocatechin Gallate and Caffeine Differentially Inhibit the Intestinal Absorption of Cholesterol and Fat in Ovariectomized Rats J. Nutr., November 1, 2006; 136(11): 2791 - 2796. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Vlachopoulos, N. Alexopoulos, I. Dima, K. Aznaouridis, I. Andreadou, and C. Stefanadis Acute Effect of Black and Green Tea on Aortic Stiffness and Wave Reflections J. Am. Coll. Nutr., June 1, 2006; 25(3): 216 - 223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Hirano-Ohmori, R. Takahashi, Y. Momiyama, H. Taniguchi, A. Yonemura, S. Tamai, K. Umegaki, H. Nakamura, K. Kondo, and F. Ohsuzu Green Tea Consumption and Serum Malondialdehyde-Modified LDL Concentrations in Healthy Subjects J. Am. Coll. Nutr., October 1, 2005; 24(5): 342 - 346. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Williamson and C. Manach Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies Am. J. Clinical Nutrition, January 1, 2005; 81(1): 243S - 255S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M Henning, Y. Niu, N. H Lee, G. D Thames, R. R Minutti, H. Wang, V. L. W Go, and D. Heber Bioavailability and antioxidant activity of tea flavanols after consumption of green tea, black tea, or a green tea extract supplement Am. J. Clinical Nutrition, December 1, 2004; 80(6): 1558 - 1564. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. O Dragsted, A. Pedersen, A. Hermetter, S. Basu, M. Hansen, G. R Haren, M. Kall, V. Breinholt, J. J. Castenmiller, J. Stagsted, et al. The 6-a-day study: effects of fruit and vegetables on markers of oxidative stress and antioxidative defense in healthy nonsmokers Am. J. Clinical Nutrition, June 1, 2004; 79(6): 1060 - 1072. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Frei and J. V. Higdon Antioxidant Activity of Tea Polyphenols In Vivo: Evidence from Animal Studies J. Nutr., October 1, 2003; 133(10): 3275S - 3284. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Rietveld and S. Wiseman Antioxidant Effects of Tea: Evidence from Human Clinical Trials J. Nutr., October 1, 2003; 133(10): 3285S - 3292. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. D Sesso, R. S Paffenbarger Jr, Y. Oguma, and I-M. Lee Lack of association between tea and cardiovascular disease in college alumni Int. J. Epidemiol., August 1, 2003; 32(4): 527 - 533. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J Murphy, A. K Chronopoulos, I. Singh, M. A Francis, H. Moriarty, M. J Pike, A. H Turner, N. J Mann, and A. J Sinclair Dietary flavanols and procyanidin oligomers from cocoa (Theobroma cacao) inhibit platelet function Am. J. Clinical Nutrition, June 1, 2003; 77(6): 1466 - 1473. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. B. Loest, S. K. Noh, and S. I. Koo Green Tea Extract Inhibits the Lymphatic Absorption of Cholesterol and {alpha}-Tocopherol in Ovariectomized Rats J. Nutr., June 1, 2002; 132(6): 1282 - 1288. [Abstract] [Full Text] [PDF]
|
|
