QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ziegler, T. R. Search for Related Content PubMed PubMed Citation Articles by Ziegler, T. R.

---

Supplement

Glutamine Supplementation in Cancer Patients Receiving Bone Marrow Transplantation and High Dose Chemotherapy^{1 ,2}

Department of Medicine, Division of Endocrinology and Metabolism, Emory University School of Medicine, Atlanta, GA 30322

³To whom correspondence should be addressed. E-mail: tzieg01{at}emory.edu

Glutamine supplementation of enteral and parenteral nutrition support has received increased attention in the research community over the past decade. Glutamine may become a conditionally essential nutrient during certain catabolic states, including after bone marrow transplantation (BMT). The administration of enteral or parenteral glutamine seems safe and also potentially efficacious in some patient groups undergoing intensive treatment for cancer. Studies indicate that adjunctive glutamine treatment may improve nitrogen retention, decrease clinical infection and length of hospital stay and reduce the incidence and severity of mucositis after BMT and high dose chemotherapy. Although not all studies demonstrate benefit, there are sufficient positive data to suggest that this nutrient should be considered in the metabolic support of many individuals undergoing the catabolic process of marrow transplantation. Given the available data, randomized, double-blind, controlled clinical trials of glutamine-enriched nutrition in patients receiving BMT and high dose chemotherapy protocols are indicated to further define the utility of this amino acid as adjunctive therapy. Studies of glutamine nutrition combined with current combinations of cytoreductive agents and hematopoietic growth factors in BMT will be particularly pertinent.

KEY WORDS: • glutamine • bone marrow transplantation • chemotherapy

This article has been cited by other articles:

				L. Doepel, G. E. Lobley, J. F. Bernier, P. Dubreuil, and H. Lapierre Effect of Glutamine Supplementation on Splanchnic Metabolism in Lactating Dairy Cows J Dairy Sci, September 1, 2007; 90(9): 4325 - 4333. [Abstract] [Full Text] [PDF]

				C. R. Heiser, J. A. Ernst, J. T. Barrett, N. French, M. Schutz, and M. P. Dube Probiotics, Soluble Fiber, and L-Glutamine (GLN) Reduce Nelfinavir (NFV)or Lopinavir/Ritonavir (LPV/r)-related Diarrhea J Int Assoc Physicians AIDS Care (Chic Ill), October 1, 2004; 3(4): 121 - 129. [Abstract] [PDF]