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Research Communication

Vitamin B-6–Supplemented Diets Compared with a Low Vitamin B-6 Diet Suppress Azoxymethane-Induced Colon Tumorigenesis in Mice by Reducing Cell Proliferation

Shun-ichiro Komatsu, Hiromitsu Watanabe^*, Tatsuzo Oka, Haruhito Tsuge^**, Hironori Nii^** and Norihisa Kato

Faculty of Applied Biochemistry, Hiroshima University, Higashi-Hiroshima 739-8528, Japan; ^* Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, Japan; Faculty of Agriculture, Kagoshima University, Kagoshima 890-0065, Japan; and ^** Faculty of Agriculture, Gifu University, Gifu 501-

¹To whom correspondence should be addressed. E-mail: nkato{at}hiroshima-u.ac.jp.

Male ICR mice were examined for the effect of vitamin B-6 [pyridoxine (PN) HCl] on azoxymethane-induced colon tumorigenesis. Mice were fed the diets containing 1, 7, 14 or 35 mg PN HCl/kg for 22 wk, and given a weekly injection of azoxymethane (5 mg/kg body) for the initial 10 wk. Compared with the 1 mg PN HCl/kg diet, 7, 14 and 35 mg PN HCl/kg diets significantly suppressed the incidence and number of colon tumors, colon cell proliferation and expressions of c-myc and c-fos proteins. For some variables, 14 and 35 mg PN HCl/kg diets were more effective than the 7 mg/kg diet. Supplemental vitamin B-6 had no influence on the number of colon apoptotic cells. The results suggest that elevating dietary vitamin B-6 suppresses colon tumorigenesis by reducing cell proliferation.

KEY WORDS: • vitamin B-6 • pyridoxine • colon tumorigenesis • cell proliferation • mice

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