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Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Canada M5S 3E2 and * Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Canada M5S 1A8
3To whom correspondence should be addressed. E-mail: harvey.anderson{at}utoronto.ca.
The hypothesis that peripheral glucagon-like peptide-1 (GLP-1) is a regulator of both food intake and macronutrient selection in rats was tested by administration of its antagonist, exendin 9–39, and its agonist, exendin 4. The effect of exendin 9–39 given intraperitoneally (i.p.) on food intake was measured after carbohydrate, protein or fat preloads, and on choice between a protein-free, high carbohydrate (CHO) diet and a high protein, low carbohydrate (PRO) diet. The effect of exendin 4 on selection between the CHO and PRO diets was also investigated. Exendin 9–39 significantly enhanced food intake suppression occurring after glucose, but not after corn oil or albumin preloads. In diet selection studies, exendin 9–39 selectively decreased intake of only the CHO diet. In contrast, exendin 4 decreased intake of only the PRO diet. Thus, we suggest that peripheral GLP-1 plays a role in the regulation of macronutrient selection as well as food intake in rats.
KEY WORDS: • gut peptide • high protein, low carbohydrate diet • intraperitoneal administration • protein-free, high carbohydrate diet • rats
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