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Department of Physiology and * Aging Research and Education Center, The University of Texas Health Science Center, San Antonio, TX 78229-3900
3To whom correspondence should be addressed. E-mail: Han{at}uthscsa.edu.
Because neuroendocrine mechanisms may contribute to the antiaging
effects of food restriction (FR), we measured the effect of FR on mRNAs
encoding anterior pituitary (AP) tropic hormones. Slot blots or RNase
protection assays were done on AP RNA from 3-, 6-, 12-, 18- and
24-mo-old male F344 rats consuming food ad libitum (AL) or food
restricted (FR; to 60% of AL food intake) from 6 wk. Both AL and FR
rats gained body weight during the study (P < 0.05), but FR rats weighed 
40% less (P < 0.0001). Messenger RNA levels were expressed in two ways, i.e., per
total AP and per microgram total AP RNA. Proopiomelanocortin (POMC)
mRNA/µg RNA was higher (P < 0.0005) in FR than in AL rats at all ages. Thyroid-stimulating
hormone (TSH) ß mRNA declined with age (P < 0.05) in AL but not FR rats and was reduced by FR up to 12 mo
(P < 0.01). Growth hormone (GH)
mRNA/µg RNA declined with age (P
< 0.05) in AL but not FR rats, and total GH mRNA in the AP was
reduced by FR at early ages (P < 0.05). FR reduced
prolactin (PRL) mRNA and its age-related increase (P
< 0.0005). Levels of luteinizing hormone (LH) ß and
follicle-stimulating hormone (FSH) ß mRNAs did not differ between
AL and FR rats until 12 mo, but thereafter rose in FR (LH ß mRNA;
P < 0.01, FSH ß mRNA; P < 0.05). Many of these changes in gene expression corroborate previously
reported hormonal changes in FR rodents and mutant mice with extended
life spans, and thus provide further support for the hypothesis that an
altered hormonal milieu contributes to the antiaging effects of food
restriction.
KEY WORDS: • neuroendocrine • Fischer 344 rats • food restriction
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