QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Coté, G. L. Search for Related Content PubMed PubMed Citation Articles by Coté, G. L.

---

Supplement

Noninvasive and Minimally-Invasive Optical Monitoring Technologies^{1 ,2}

Biomedical Engineering Program, Texas A&M University, College Station, TX 77843-3120

³To whom correspondence should be addressed. E-mail: cote{at}tamu.edu

With recent advancements in micro-fabrication and nano-fabrication techniques as well as advancements in the photonics industry, there is now the potential to develop less invasive portable sensors for monitoring micronutrients and other substances used to assess overall health. There have been many technology innovations in the central laboratory for these substances for overall health status but the primary motivation for the research and development of a portable field instrument has come from a diabetic patient and market-driven desire to minimally invasively or noninvasively monitor glucose concentrations in vivo. Such a sensor system has the potential to significantly improve the quality of life for the estimated 16 million diabetics in this country by making routine glucose measurements less painful and more convenient. In addition, there is a critical need for the development of less invasive portable technologies to assess micronutrient status (iron, vitamin A, iodine and folate), environmental hazards (lead) and for other disease-related substances, such as billirubin for infant jaundice. Currently, over 100 small companies and universities are working to develop improved monitoring devices, primarily for glucose, and optical methods are a big part of these efforts. In this article many of these potentially less invasive and portable optical sensing technologies, which are currently under investigation, will be reviewed including optical absorption spectroscopy, polarimetry, Raman spectroscopy and fluorescence.

KEY WORDS: • polarimetry • spectroscopy • fluorescence • micronutrients • glucose

This article has been cited by other articles:

				J. H. Thrall Nanotechnology and Medicine Radiology, February 1, 2004; 230(2): 315 - 318. [Full Text] [PDF]

				J. D. Hirschman and J. A. Kresge Synthesis of a Symposium: Innovative Non- or Minimally-Invasive Technologies for Monitoring Health and Nutritional Status in Mothers and Young Children J. Nutr., May 1, 2001; 131(5): 1643S - 1645. [Full Text]