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,**,
*
National Institute for Food and Nutrition Research, 00178 Rome, Italy; Departments of
Medical Physiopathology and
**
Histology Medical Embryology, University "La Sapienza," 00161 Rome, Italy;
Department of Experimental Medicine, University of L’Aquila, 67100 L’Aquila, Italy and
Laboratory of Pediatric Endocrinology, University "Tor Vergata," 00133 Rome, Italy
2To whom correspondence should be addressed at National Institute for Food and Nutrition Research, via Ardeatina 546, 00178 Rome, Italy. E-mail: F.Branca{at}agora.stm.it
We investigated the effects of dietary zinc deficiency on skeletal metabolism in an animal model. Thirty 21-d-old male Sprague-Dawley rats were fed for 28 d either a zinc-deficient (ZD) diet (1 mg zinc/kg) or a normal diet ad libitum (AL, 50 mg zinc/kg) or in the same quantity as the ZD (pair-fed, PF). Only in the ZD group were general physical signs of zinc deficiency observed. Compared with the AL and PF rats, ZD rats showed significantly lower mean values in ponderal growth rate, femur weight and length, circulating levels of insulin-like growth factor-I, bone mechanical properties and concentration of zinc and, on histomorphometry, a decrease in the thicknesses of the overall growth plate and hypertrophic cartilage. In contrast, although bone volume was significantly lower in the ZD and PF rats than in the AL rats, no difference was observed between the ZD and PF rats. Osteoclast surface/bone surface and osteoclast number/bone surface ratios were significantly greater in PF rats than in the other two groups and not different in ZD and AL rats. Collectively, these data indicate that zinc deficiency has profound effects on the skeletal system of growing rats. In particular, the effects of zinc deficiency on bone growth and mass are the result of the reduced activity of the growth plate, likely mediated by impairment in the insulin-like growth factor-I system. We did not demonstrate an effect on bone mass via increased bone resorption.
KEY WORDS: • zinc deficiency • rats • histomorphometry • growth cartilage
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