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Energy Expenditure in Infants with Pulmonary Insufficiency: Is There Evidence for Increased Energy Needs?^{1 ,2}

Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, Indianapolis, IN 46202

³To whom correspondence and reprint requests should be addressed at 699 West Drive, RR 208, Indianapolis, IN 46202. E-mail: sdenne{at}iupui.edu

The observed growth failure in infants with pulmonary insufficiency is postulated to be a consequence of elevated rates of energy expenditure. Assessment of energy expenditure by the classical technique of indirect calorimetry has yielded conflicting results. The adoption of the newer, doubly labeled water technique has provided evidence to support increased rates of energy expenditure in infants with chronic lung disease, congenital heart disease and in minimally ill, extremely low birth weight infants. The doubly labeled water technique holds great promise for the detailed study of energy expenditure in a variety of clinical conditions, including very ill as well as free-living subjects.

KEY WORDS: • energy expenditure • rate of growth • pulmonary insufficiency

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