QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Chambon-Savanovitch, C. Articles by Vasson ;, M.-P. Search for Related Content PubMed PubMed Citation Articles by Chambon-Savanovitch, C. Articles by Vasson ;, M.-P.

---

Articles

A Pancreatic Extract–Enriched Diet Improves the Nutritional Status of Aged Rats^{1 ,2}

Chantal Chambon-Savanovitch, Catherine Felgines, Stéphane Walrand, Francis Raul^*, Setareh Zarrabian, Marie-Thérèse Meunier, Marie-Chantal Farges, Luc Cynober and Marie-Paule Vasson³ ;

Laboratory of Biochemistry, Molecular Biology and Nutrition, Pharmacy School, EA 2416, Human Nutrition Research Center, Clermont-Ferrand, France; ^* CJF INSERM 95–09, IRCAD, Strasbourg, France; and INSERM, R. Debré Hospital, Paris, France

³To whom correspondence should be addressed. E-mail: M-Paule.VASSON{at}uclermont1.fr

Correction of the malnourished state, particularly common and severe in elderly people, is often unsuccessful. To improve the efficiency of realimentation, we evaluated the nutritional effect of a pancreatic extract (PE)-enriched diet in malnourished aged rats. Sprague-Dawley male rats were randomly assigned to 6 groups as follows: 1 group of control rats had free access to the diet for 12 wk (C group) and 5 groups were 50% food restricted for the same period. One food-restricted group was then killed (R group) and the 4 remaining groups were refed for 1 wk using a standard diet enriched either with two different doses of a pancreatic extract (2.4 or 4.8 g/d in PE₁ and PE₂ groups, respectively) or with an isonitrogenous casein hydrolysate (CH₁ and CH₂ groups, respectively). Profound alterations induced by food restriction (FR) were moderately corrected by refeeding, except nitrogen balance, which was reestablished in rats refed all diets (P < 0.01 vs. R). Supplementation of the food ration with a pancreatic extract clearly improved recovery. Indeed, body weight gain, both jejunal and ileal trophicity [jejunum: total height, PE₂: 849 ± 45 µm vs. CH₂: 768 ± 17 µm (P < 0.05); protein content, PE₂: 69.9 ± 5.7 mg vs. CH₂: 56.4 ± 4.8 mg (P < 0.01)] and nonspecific immune response in terms of H₂O₂ production by polymorphonuclear neutrophils and tumor necrosis factor (TNF-) by macrophages (PE₂, 20.7 ± 4.7 vs. CH₂, 8.7 ± 2.3, P < 0.05) were improved in rats fed PE₂. A pancreatic extract could improve the efficiency of realimentation in malnourished aged rats.

KEY WORDS: • rats • aging • malnutrition • casein hydrolysate • pancreatic extract

This article has been cited by other articles:

				C. Moinard and L. Cynober Citrulline: A New Player in the Control of Nitrogen Homeostasis J. Nutr., June 1, 2007; 137(6): 1621S - 1625S. [Abstract] [Full Text] [PDF]

				H. J. Thompson, Z. Zhu, and W. Jiang Protection against Cancer by Energy Restriction: All Experimental Approaches Are Not Equal J. Nutr., May 1, 2002; 132(5): 1047 - 1049. [Full Text] [PDF]