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(Journal of Nutrition. 2001;131:1058S-1060S.)
© 2001 The American Society for Nutritional Sciences

Supplement: Recent Advances on the Nutritional Effects Associated with the Use of Garlic as a Supplement

Antiproliferative Effects of Allium Derivatives from Garlic1 ,2

John T. Pinto3 and Richard S. Rivlin

Memorial Sloan-Kettering Cancer Center, New York, NY 10021 and Weill Medical College of Cornell University, New York, NY 10021

3To whom correspondence should be addressed. E-mail: pintoj{at}mskcc.org

ABSTRACT

There is increasing evidence that allium derivatives from garlic have significant antiproliferative actions on human cancers. Both hormone-responsive and hormone-unresponsive cells lines respond to these derivatives. The effects shown by allium derivatives include induction of apoptosis, regulation of cell cycle progression and modification of pathways of signal transduction. Allium derivatives appear to regulate nuclear factors involved in immune function and inflammation, as well as in cellular proliferation. Our own studies indicate that allium derivatives inhibit proliferation of the human prostate cancer cell line (LNCaP) and the human breast cancer cell line (MCF-7). Further research is required to clarify the mechanisms of inhibition of cellular proliferation by allium derivatives and to explore their potential application to cancer prevention and control.

KEY WORDS: • garlic • allium • human prostate cancer • LNCaP cells • human breast cancer • MCF-7 cells




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