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Articles

Older Men and Women Efficiently Absorb Vitamin B-12 from Milk and Fortified Bread^{1 ,2}

Robert M. Russell^*3, Hyun Baik and Joseph J. Kehayias^*

^* Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111 and Ilsan Paik Hospital, School of Medicine, Inje University, Kyungkido, Korea

³To whom correspondence should be addressed U.S. Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111. E-mail: russell{at}hnrc.tufts.edu

Nothing is directly known about the bioavailability of vitamin B-12 from dairy products or fortified grain products. We directly studied vitamin B-12 absorption from water, milk and fortified bread in adult subjects using ⁵⁸Co-labeled vitamin B-12 and a whole body gamma-ray counter/spectrophotometer. Sixteen healthy men and women over the age of 60 y with normal serum levels of vitamin B-12 and normal basal gastric acid secretion were studied. ⁵⁸Co vitamin B-12 (0.25 µg) was administered in water, milk or fortified bread to each subject along with 185 kBq (5.0 µCi) ⁵¹Cr as a stool marker. Whole body counting was performed 30 min after ingestion of the radioactive dose and at 7 and 14 d after dosing. Mean absorptions from water, milk and fortified bread were 55, 65 and 55%, respectively, and did not differ. The high body retention of the extrinsic vitamin B-12 label from milk and bread may warrant a greater use of such fortified products in the elderly to ensure vitamin B-12 adequacy.

KEY WORDS: • vitamin B-12 • vitamin B-12 bioavailability • vitamin B-12 absorption • humans

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