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Articles

Research Needs for Human Nutrition in the Post–Genome-Sequencing Era¹

Departments of Nutritional Sciences and Biochemistry, University of Missouri, Columbia, MO 65211

²To whom correspondence should be addressed. E-mail: sunder{at}missouri.edu.

The sequencing and annotation of the human genome and the genomes of other model organisms offer new tools and new opportunities for human nutrition research in the 21st century. Basic research continues to be the key foundation for formulating solid nutrition recommendations for the public, but the basis for establishing human nutrient recommendations today suffers because of lack of good biomarkers and because of weak federal funding for nutrition research. In the context of this post–human genome-sequencing era, tantalizing opportunity exists in seven areas—four basic and three applied: 1) identification of molecular biomarkers for nutrient status; 2) characterization of single polynuclear polymorphisms (SNPs) associated with nutrition; 3) development of a national genome array nutrition database; 4) use of models at all phylogenetic levels for nutrition research; 5) application of post–genome-sequencing tools to study diet and human health, including phytonutrients and genetically modified foods; 6) application of these tools to the role of nutrition in pathogenesis of human disease; and 7) development of a funding base for research on exercise and human health.

KEY WORDS: • exercise • genome array database • National Research Initiative • nutrient biomarkers • single polynuclear polymorphisms.

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