QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Grube, B. J Articles by Chen, S. Search for Related Content PubMed PubMed Citation Articles by Grube, B. J Articles by Chen, S.

---

Articles

White Button Mushroom Phytochemicals Inhibit Aromatase Activity and Breast Cancer Cell Proliferation^{1 ,2}

Division of Immunology, Beckman Research Institute of the City of Hope, Duarte, CA 91010

⁴To whom correspondence should be addressed. E-mail: schen{at}coh.org.

Estrogen is a major factor in the development of breast cancer. In situ estrogen production by aromatase/estrogen synthetase in breast cancer plays a dominant role in tumor proliferation. Because natural compounds such as flavones and isoflavones have been shown to be inhibitors of aromatase, it is thought that vegetables that contain these phytochemicals can inhibit aromatase activity and suppress breast cancer cell proliferation. Heat-stable extracts were prepared from vegetables and screened for their ability to inhibit aromatase activity in a human placental microsome assay. The white button mushroom (species Agaricus bisporus) suppressed aromatase activity dose dependently. Enzyme kinetics demonstrated mixed inhibition, suggesting the presence of multiple inhibitors or more than one inhibitory mechanism. "In cell" aromatase activity and cell proliferation were measured using MCF-7aro, an aromatase-transfected breast cancer cell line. Phytochemicals in the mushroom aqueous extract inhibited aromatase activity and proliferation of MCF-7aro cells. These results suggest that diets high in mushrooms may modulate the aromatase activity and function in chemoprevention in postmenopausal women by reducing the in situ production of estrogen.

KEY WORDS: • breast cancer • aromatase • white button mushrooms • diet and cancer prevention

This article has been cited by other articles:

				S. Chen, S.-R. Oh, S. Phung, G. Hur, J. J. Ye, S. L. Kwok, G. E. Shrode, M. Belury, L. S. Adams, and D. Williams Anti-Aromatase Activity of Phytochemicals in White Button Mushrooms (Agaricus bisporus) Cancer Res., December 15, 2006; 66(24): 12026 - 12034. [Abstract] [Full Text] [PDF]

				Y. Wang, K. W. Lee, F. L. Chan, S. Chen, and L. K. Leung The Red Wine Polyphenol Resveratrol Displays Bilevel Inhibition on Aromatase in Breast Cancer Cells Toxicol. Sci., July 1, 2006; 92(1): 71 - 77. [Abstract] [Full Text] [PDF]