QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hartmann, P. Articles by Cregan, M. Search for Related Content PubMed PubMed Citation Articles by Hartmann, P. Articles by Cregan, M.

---

Symposium: Human Lactogenesis II: Mechanisms, Determinants and Consequences

Lactogenesis and the Effects of Insulin-Dependent Diabetes Mellitus and Prematurity^{1 ,2}

Department of Biochemistry, University of Western Australia, Crawley, WA 6009, Australia

³To whom correspondence should be addressed. E-mail: hartmanp{at}cyllene.uwa.edu.au

The initiation of lactation (lactogenesis II) by the mother must be synchronized to the delivery of the infant, permitting the transition of the newborn from continuous nourishment from the umbilical cord to comparable but intermittent life support from its mother’s breasts. The onset of lactogenesis II can be adversely affected by a variety of factors. Over 80% of women who have delivered prematurely and are expressing milk for their infant had a compromised initiation of lactation, that is one or more lactogenesis II markers (lactose, citrate, sodium and total protein) in their milk > 3 SD from the mean of the full-term women on d 5 postpartum. Similarly, the lactogenesis II markers (lactose, citrate and total nitrogen) in the milk of women with insulin-dependent diabetes mellitus take an additional 24 h to attain the concentrations of normal women. The mechanisms that lead to the development of delayed or compromised onset of lactogenesis II in women are poorly understood and require additional research.

KEY WORDS: • lactogenesis • prematurity • diabetes • progesterone

This article has been cited by other articles:

				E. P. Gunderson Breastfeeding After Gestational Diabetes Pregnancy: Subsequent obesity and type 2 diabetes in women and their offspring Diabetes Care, July 1, 2007; 30(Supplement_2): S161 - S168. [Full Text] [PDF]

				K. G. Dewey, L. A. Nommsen-Rivers, M. J. Heinig, and R. J. Cohen Risk Factors for Suboptimal Infant Breastfeeding Behavior, Delayed Onset of Lactation, and Excess Neonatal Weight Loss Pediatrics, September 1, 2003; 112(3): 607 - 619. [Abstract] [Full Text] [PDF]