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Symposium: Translational Control: A Mechanistic Perspective

Regulation of Translation via TOR Signaling: Insights from Drosophila melanogaster^{1 ,2}

Department of Biochemistry and McGill Cancer Center, McGill University, Montréal, Québec, Canada

³To whom correspondence should be addressed. E-mail: nsonen{at}med.mcgill.ca

The target of rapamycin (TOR) proteins are large protein kinases evolutionarily conserved from yeast to human. A large body of evidence demonstrates that TOR proteins function in a nutrient-sensing checkpoint whose role is to restrict growth under conditions of low nutrient availability. Under such conditions, TOR blocks the transmission of growth-promoting signals from extracellular stimuli. Recent data obtained by genetic studies in the fruit fly Drosophila melanogaster demonstrate the importance of both insulin-like signaling and TOR signaling in promoting growth. Importantly, these studies identified a major downstream target of TOR and insulin-like signaling as the translational machinery.

KEY WORDS: • rapamycin • target of rapamycin • insulin-like signaling • translational control

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