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Nutritional Neurosciences

Oral Administration of Soybean Lecithin Transphosphatidylated Phosphatidylserine Improves Memory Impairment in Aged Rats

Yakult Central Institute for Microbiological Research, 1796 Yaho, Kunitachi, Tokyo 186-8650, Japan

¹To whom correspondence should be addressed. E-mail: masashi-sakai{at}yakult.co.jp

ABSTRACT

Soybean lecithin transphosphatidylated phosphatidylserine (SB-tPS) was prepared from soybean lecithin and L-serine by a transphosphatidylation reaction, and its effect on age-related memory impairment was evaluated in rats by the Morris water maze test. Continuous oral administration of SB-tPS (60 mg·kg^-1·d^-1 for 60 d) to male aged rats (24–25 mo) significantly improved performance in the water maze escape test (P < 0.01 vs. control aged rats) similar to bovine brain cortex-derived phosphatidylserine, which restores cognitive function in patients with senile dementia. SB-tPS also increased acetylcholine release and the Na⁺, K⁺-ATPase activity of the synaptosomes prepared from these aged rats to the level in young rats. The nootropic actions of SB-tPS in the present study can be partly explained by the changes in these biochemical activities.

KEY WORDS: • soybean • lecithin • transphosphatidylated phosphatidylserine • spatial memory impairment • acetylcholine • Na⁺,K⁺-ATPase • rats

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